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St. John's wort extract and hyperforin inhibit multiple phosphorylation steps of cytokine signaling and prevent inflammatory and apoptotic gene induction in pancreatic β cells.
Novelli M, Menegazzi M, Beffy P, Porozov S, Gregorelli A, Giacopelli D, De Tata V, Masiello P. Novelli M, et al. Among authors: gregorelli a. Int J Biochem Cell Biol. 2016 Dec;81(Pt A):92-104. doi: 10.1016/j.biocel.2016.10.017. Epub 2016 Oct 22. Int J Biochem Cell Biol. 2016. PMID: 27780755