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Hydroxyurea differentially modulates activator and repressors of γ-globin gene in erythroblasts of responsive and non-responsive patients with sickle cell disease in correlation with Index of Hydroxyurea Responsiveness.
Zhu X, Hu T, Ho MH, Wang Y, Yu M, Patel N, Pi W, Choi JH, Xu H, Ganapathy V, Kutlar F, Kutlar A, Tuan D. Zhu X, et al. Among authors: kutlar f. Haematologica. 2017 Dec;102(12):1995-2004. doi: 10.3324/haematol.2017.175646. Epub 2017 Sep 29. Haematologica. 2017. PMID: 28971909 Free PMC article.
Missense mutation of the last nucleotide of exon 1 (G->C) of beta globin gene not only leads to undetectable mutant peptide and transcript but also interferes with the expression of wild allele.
Agarwal N, Kutlar F, Mojica-Henshaw MP, Ou CN, Gaikwad A, Reading NS, Bailey L, Kutlar A, Prchal JT. Agarwal N, et al. Among authors: kutlar f, kutlar a. Haematologica. 2007 Dec;92(12):1715-6. doi: 10.3324/haematol.11543. Haematologica. 2007. PMID: 18056002 Free article.
152 results