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HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections.
Sun L, Jiang Z, Acosta-Rodriguez VA, Berger M, Du X, Choi JH, Wang J, Wang KW, Kilaru GK, Mohawk JA, Quan J, Scott L, Hildebrand S, Li X, Tang M, Zhan X, Murray AR, La Vine D, Moresco EMY, Takahashi JS, Beutler B. Sun L, et al. Among authors: hildebrand s. J Exp Med. 2017 Nov 6;214(11):3263-3277. doi: 10.1084/jem.20161630. Epub 2017 Oct 2. J Exp Med. 2017. PMID: 28970238 Free PMC article.
Real-time resolution of point mutations that cause phenovariance in mice.
Wang T, Zhan X, Bu CH, Lyon S, Pratt D, Hildebrand S, Choi JH, Zhang Z, Zeng M, Wang KW, Turer E, Chen Z, Zhang D, Yue T, Wang Y, Shi H, Wang J, Sun L, SoRelle J, McAlpine W, Hutchins N, Zhan X, Fina M, Gobert R, Quan J, Kreutzer M, Arnett S, Hawkins K, Leach A, Tate C, Daniel C, Reyna C, Prince L, Davis S, Purrington J, Bearden R, Weatherly J, White D, Russell J, Sun Q, Tang M, Li X, Scott L, Moresco EM, McInerney GM, Karlsson Hedestam GB, Xie Y, Beutler B. Wang T, et al. Among authors: hildebrand s. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E440-9. doi: 10.1073/pnas.1423216112. Epub 2015 Jan 20. Proc Natl Acad Sci U S A. 2015. PMID: 25605905 Free PMC article.
NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component.
Shi H, Wang Y, Li X, Zhan X, Tang M, Fina M, Su L, Pratt D, Bu CH, Hildebrand S, Lyon S, Scott L, Quan J, Sun Q, Russell J, Arnett S, Jurek P, Chen D, Kravchenko VV, Mathison JC, Moresco EM, Monson NL, Ulevitch RJ, Beutler B. Shi H, et al. Among authors: hildebrand s. Nat Immunol. 2016 Mar;17(3):250-8. doi: 10.1038/ni.3333. Epub 2015 Dec 7. Nat Immunol. 2016. PMID: 26642356 Free PMC article.
IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice.
Choi JH, Wang KW, Zhang D, Zhan X, Wang T, Bu CH, Behrendt CL, Zeng M, Wang Y, Misawa T, Li X, Tang M, Zhan X, Scott L, Hildebrand S, Murray AR, Moresco EM, Hooper LV, Beutler B. Choi JH, et al. Among authors: hildebrand s. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1196-E1204. doi: 10.1073/pnas.1621258114. Epub 2017 Jan 30. Proc Natl Acad Sci U S A. 2017. PMID: 28137874 Free PMC article.
Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5.
Zhang D, Tomisato W, Su L, Sun L, Choi JH, Zhang Z, Wang KW, Zhan X, Choi M, Li X, Tang M, Castro-Perez JM, Hildebrand S, Murray AR, Moresco EMY, Beutler B. Zhang D, et al. Among authors: hildebrand s. Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5197-E5206. doi: 10.1073/pnas.1705312114. Epub 2017 Jun 12. Proc Natl Acad Sci U S A. 2017. PMID: 28607088 Free PMC article.
Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice.
Wang Y, Su L, Morin MD, Jones BT, Mifune Y, Shi H, Wang KW, Zhan X, Liu A, Wang J, Li X, Tang M, Ludwig S, Hildebrand S, Zhou K, Siegwart DJ, Moresco EMY, Zhang H, Boger DL, Beutler B. Wang Y, et al. Among authors: hildebrand s. Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8698-E8706. doi: 10.1073/pnas.1809232115. Epub 2018 Aug 27. Proc Natl Acad Sci U S A. 2018. PMID: 30150374 Free PMC article.
Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation.
Misawa T, SoRelle JA, Choi JH, Yue T, Wang KW, McAlpine W, Wang J, Liu A, Tabeta K, Turer EE, Evers B, Nair-Gill E, Poddar S, Su L, Ou F, Yu L, Russell J, Ludwig S, Zhan X, Hildebrand S, Li X, Tang M, Murray AR, Moresco EMY, Beutler B. Misawa T, et al. Among authors: hildebrand s. Sci Immunol. 2020 Jan 24;5(43):eaaz0085. doi: 10.1126/sciimmunol.aaz0085. Sci Immunol. 2020. PMID: 31980486 Free PMC article.
Dominant atopy risk mutations identified by mouse forward genetic analysis.
SoRelle JA, Chen Z, Wang J, Yue T, Choi JH, Wang KW, Zhong X, Hildebrand S, Russell J, Scott L, Xu D, Zhan X, Bu CH, Wang T, Choi M, Tang M, Ludwig S, Zhan X, Li X, Moresco EMY, Beutler B. SoRelle JA, et al. Among authors: hildebrand s. Allergy. 2021 Apr;76(4):1095-1108. doi: 10.1111/all.14564. Epub 2020 Sep 20. Allergy. 2021. PMID: 32810290 Free PMC article.
136 results