α-Ketoglutarate prevents skeletal muscle protein degradation and muscle atrophy through PHD3/ADRB2 pathway.
Cai X, Yuan Y, Liao Z, Xing K, Zhu C, Xu Y, Yu L, Wang L, Wang S, Zhu X, Gao P, Zhang Y, Jiang Q, Xu P, Shu G.
Cai X, et al. Among authors: zhu c, zhu x.
FASEB J. 2018 Jan;32(1):488-499. doi: 10.1096/fj.201700670R. Epub 2017 Sep 22.
FASEB J. 2018.
PMID: 28939592
Free PMC article.
These findings not only provide a molecular basis for the potential use of exercise-generated metabolite AKG in muscle atrophy treatment, but also identify PHD3 as a potential target for the development of therapies for muscle wasting.-Cai, X., Yuan, Y., Liao, Z., Xing, K., Zh …
These findings not only provide a molecular basis for the potential use of exercise-generated metabolite AKG in muscle atrophy treatment, bu …