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A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase.
Lahav D, Liu B, van den Berg RJBHN, van den Nieuwendijk AMCH, Wennekes T, Ghisaidoobe AT, Breen I, Ferraz MJ, Kuo CL, Wu L, Geurink PP, Ovaa H, van der Marel GA, van der Stelt M, Boot RG, Davies GJ, Aerts JMFG, Overkleeft HS. Lahav D, et al. Among authors: wu l. J Am Chem Soc. 2017 Oct 11;139(40):14192-14197. doi: 10.1021/jacs.7b07352. Epub 2017 Sep 29. J Am Chem Soc. 2017. PMID: 28937220 Free PMC article.
Manno-epi-cyclophellitols Enable Activity-Based Protein Profiling of Human α-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors.
Armstrong Z, Kuo CL, Lahav D, Liu B, Johnson R, Beenakker TJM, de Boer C, Wong CS, van Rijssel ER, Debets MF, Florea BI, Hissink C, Boot RG, Geurink PP, Ovaa H, van der Stelt M, van der Marel GM, Codée JDC, Aerts JMFG, Wu L, Overkleeft HS, Davies GJ. Armstrong Z, et al. Among authors: wu l. J Am Chem Soc. 2020 Jul 29;142(30):13021-13029. doi: 10.1021/jacs.0c03880. Epub 2020 Jul 16. J Am Chem Soc. 2020. PMID: 32605368
1,6-epi-Cyclophellitol Cyclosulfamidate Is a Bona Fide Lysosomal α-Glucosidase Stabilizer for the Treatment of Pompe Disease.
Kok K, Kuo CL, Katzy RE, Lelieveld LT, Wu L, Roig-Zamboni V, van der Marel GA, Codée JDC, Sulzenbacher G, Davies GJ, Overkleeft HS, Aerts JMFG, Artola M. Kok K, et al. Among authors: wu l. J Am Chem Soc. 2022 Aug 17;144(32):14819-14827. doi: 10.1021/jacs.2c05666. Epub 2022 Aug 2. J Am Chem Soc. 2022. PMID: 35917590 Free PMC article.
Gluco-1 H-imidazole: A New Class of Azole-Type β-Glucosidase Inhibitor.
Schröder SP, Wu L, Artola M, Hansen T, Offen WA, Ferraz MJ, Li KY, Aerts JMFG, van der Marel GA, Codée JDC, Davies GJ, Overkleeft HS. Schröder SP, et al. Among authors: wu l. J Am Chem Soc. 2018 Apr 18;140(15):5045-5048. doi: 10.1021/jacs.8b02399. Epub 2018 Apr 4. J Am Chem Soc. 2018. PMID: 29601200 Free PMC article.
An overview of activity-based probes for glycosidases.
Wu L, Armstrong Z, Schröder SP, de Boer C, Artola M, Aerts JM, Overkleeft HS, Davies GJ. Wu L, et al. Curr Opin Chem Biol. 2019 Dec;53:25-36. doi: 10.1016/j.cbpa.2019.05.030. Epub 2019 Aug 13. Curr Opin Chem Biol. 2019. PMID: 31419756 Review.
Bacterial β-Glucosidase Reveals the Structural and Functional Basis of Genetic Defects in Human Glucocerebrosidase 2 (GBA2).
Charoenwattanasatien R, Pengthaisong S, Breen I, Mutoh R, Sansenya S, Hua Y, Tankrathok A, Wu L, Songsiriritthigul C, Tanaka H, Williams SJ, Davies GJ, Kurisu G, Cairns JR. Charoenwattanasatien R, et al. Among authors: wu l. ACS Chem Biol. 2016 Jul 15;11(7):1891-900. doi: 10.1021/acschembio.6b00192. Epub 2016 May 6. ACS Chem Biol. 2016. PMID: 27115290 Free PMC article.
Activity-based probes for functional interrogation of retaining β-glucuronidases.
Wu L, Jiang J, Jin Y, Kallemeijn WW, Kuo CL, Artola M, Dai W, van Elk C, van Eijk M, van der Marel GA, Codée JDC, Florea BI, Aerts JMFG, Overkleeft HS, Davies GJ. Wu L, et al. Nat Chem Biol. 2017 Aug;13(8):867-873. doi: 10.1038/nchembio.2395. Epub 2017 Jun 5. Nat Chem Biol. 2017. PMID: 28581485 Free article.
Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents.
Rowland RJ, Chen Y, Breen I, Wu L, Offen WA, Beenakker TJ, Su Q, van den Nieuwendijk AMCH, Aerts JMFG, Artola M, Overkleeft HS, Davies GJ. Rowland RJ, et al. Among authors: wu l. Chemistry. 2021 Nov 25;27(66):16377-16388. doi: 10.1002/chem.202102359. Epub 2021 Oct 29. Chemistry. 2021. PMID: 34570911 Free PMC article.
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