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Estrogen Metabolite 16α-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II-Associated Pulmonary Arterial Hypertension Through MicroRNA-29-Mediated Modulation of Cellular Metabolism.
Chen X, Talati M, Fessel JP, Hemnes AR, Gladson S, French J, Shay S, Trammell A, Phillips JA, Hamid R, Cogan JD, Dawson EP, Womble KE, Hedges LK, Martinez EG, Wheeler LA, Loyd JE, Majka SJ, West J, Austin ED. Chen X, et al. Circulation. 2016 Jan 5;133(1):82-97. doi: 10.1161/CIRCULATIONAHA.115.016133. Epub 2015 Oct 20. Circulation. 2016. PMID: 26487756 Free PMC article.
A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension.
Hemnes AR, Rathinasabapathy A, Austin EA, Brittain EL, Carrier EJ, Chen X, Fessel JP, Fike CD, Fong P, Fortune N, Gerszten RE, Johnson JA, Kaplowitz M, Newman JH, Piana R, Pugh ME, Rice TW, Robbins IM, Wheeler L, Yu C, Loyd JE, West J. Hemnes AR, et al. Among authors: chen x. Eur Respir J. 2018 Jun 21;51(6):1702638. doi: 10.1183/13993003.02638-2017. Print 2018 Jun. Eur Respir J. 2018. PMID: 29903860 Free PMC article. Clinical Trial.
BMPR2 dysfunction impairs insulin signaling and glucose homeostasis in cardiomyocytes.
Hemnes AR, Fessel JP, Chen X, Zhu S, Fortune NL, Jetter C, Freeman M, Newman JH, West JD, Talati MH. Hemnes AR, et al. Among authors: chen x. Am J Physiol Lung Cell Mol Physiol. 2020 Feb 1;318(2):L429-L441. doi: 10.1152/ajplung.00555.2018. Epub 2019 Dec 18. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 31850803 Free PMC article.
Thromboxane-Prostanoid Receptor Signaling Drives Persistent Fibroblast Activation in Pulmonary Fibrosis.
Suzuki T, Kropski JA, Chen J, Carrier EJ, Chen X, Sherrill TP, Winters NI, Camarata JE, Polosukhin VV, Han W, Rathinasabapathy A, Gutor S, Gulleman P, Sabusap C, Banovich NE, Tanjore H, Freeman ML, Tada Y, Young LR, Gokey JJ, Blackwell TS, West JD. Suzuki T, et al. Among authors: chen j, chen x. Am J Respir Crit Care Med. 2022 Sep 1;206(5):596-607. doi: 10.1164/rccm.202106-1503OC. Am J Respir Crit Care Med. 2022. PMID: 35728047 Free PMC article.
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