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Early disease progression and treatment discontinuation in patients with advanced ovarian cancer receiving immune checkpoint blockade.
Boland JL, Zhou Q, Martin M, Callahan MK, Konner J, O'Cearbhaill RE, Friedman CF, Tew W, Makker V, Grisham RN, Hensley ML, Zecca N, Iasonos AE, Snyder A, Hyman DM, Sabbatini P, Aghajanian C, Cadoo KA, Zamarin D. Boland JL, et al. Among authors: martin m. Gynecol Oncol. 2019 Feb;152(2):251-258. doi: 10.1016/j.ygyno.2018.11.025. Epub 2018 Nov 22. Gynecol Oncol. 2019. PMID: 30470581 Free PMC article.
A phase I open-label study of selinexor with paclitaxel and carboplatin in patients with advanced ovarian or endometrial cancers.
Rubinstein MM, Grisham RN, Cadoo K, Kyi C, Tew WP, Friedman CF, O'Cearbhaill RE, Zamarin D, Zhou Q, Iasonos A, Nikolovski I, Xu H, Soldan KN, Caird I, Martin M, Guillen J, Eid KT, Aghajanian C, Makker V. Rubinstein MM, et al. Among authors: martin m. Gynecol Oncol. 2021 Jan;160(1):71-76. doi: 10.1016/j.ygyno.2020.10.019. Epub 2020 Nov 1. Gynecol Oncol. 2021. PMID: 33139041 Free PMC article. Clinical Trial.
The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62.
Linares JF, Cid-Diaz T, Duran A, Osrodek M, Martinez-Ordoñez A, Reina-Campos M, Kuo HH, Elemento O, Martin ML, Cordes T, Thompson TC, Metallo CM, Moscat J, Diaz-Meco MT. Linares JF, et al. Among authors: martin ml. Cell Rep. 2022 May 10;39(6):110792. doi: 10.1016/j.celrep.2022.110792. Cell Rep. 2022. PMID: 35545049 Free PMC article.
Next generation patient derived tumor organoids.
Podaza E, Kuo HH, Nguyen J, Elemento O, Martin ML. Podaza E, et al. Among authors: martin ml. Transl Res. 2022 Dec;250:84-97. doi: 10.1016/j.trsl.2022.08.003. Epub 2022 Aug 12. Transl Res. 2022. PMID: 35964899 Review.
The regulation of CD73 in non-small cell lung cancer.
Han Y, Lee T, He Y, Raman R, Irizarry A, Martin ML, Giaccone G. Han Y, et al. Among authors: martin ml. Eur J Cancer. 2022 Jul;170:91-102. doi: 10.1016/j.ejca.2022.04.025. Epub 2022 May 19. Eur J Cancer. 2022. PMID: 35598361
Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve checkpoint blockade.
Markowitz GJ, Ban Y, Tavarez DA, Yoffe L, Podaza E, He Y, Martin MT, Crowley MJP, Sandoval TA, Gao D, Martin ML, Elemento O, Cubillos-Ruiz JR, McGraw TE, Altorki NK, Mittal V. Markowitz GJ, et al. Among authors: martin ml, martin mt. Res Sq [Preprint]. 2023 Sep 21:rs.3.rs-3356477. doi: 10.21203/rs.3.rs-3356477/v1. Res Sq. 2023. Update in: Nat Immunol. 2024 Oct;25(10):1884-1899. doi: 10.1038/s41590-024-01963-1 PMID: 37790365 Free PMC article. Updated. Preprint.
A pancreatic cancer organoid platform identifies an inhibitor specific to mutant KRAS.
Duan X, Zhang T, Feng L, de Silva N, Greenspun B, Wang X, Moyer J, Martin ML, Chandwani R, Elemento O, Leach SD, Evans T, Chen S, Pan FC. Duan X, et al. Among authors: martin ml. Cell Stem Cell. 2024 Jan 4;31(1):71-88.e8. doi: 10.1016/j.stem.2023.11.011. Epub 2023 Dec 26. Cell Stem Cell. 2024. PMID: 38151022
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