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Targeted induction of endoplasmic reticulum stress induces cartilage pathology.
Rajpar MH, McDermott B, Kung L, Eardley R, Knowles L, Heeran M, Thornton DJ, Wilson R, Bateman JF, Poulsom R, Arvan P, Kadler KE, Briggs MD, Boot-Handford RP. Rajpar MH, et al. Among authors: bateman jf. PLoS Genet. 2009 Oct;5(10):e1000691. doi: 10.1371/journal.pgen.1000691. Epub 2009 Oct 16. PLoS Genet. 2009. PMID: 19834559 Free PMC article.
Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization.
Cameron TL, Gresshoff IL, Bell KM, Piróg KA, Sampurno L, Hartley CL, Sanford EM, Wilson R, Ermann J, Boot-Handford RP, Glimcher LH, Briggs MD, Bateman JF. Cameron TL, et al. Among authors: bateman jf. Osteoarthritis Cartilage. 2015 Apr;23(4):661-70. doi: 10.1016/j.joca.2015.01.001. Epub 2015 Jan 17. Osteoarthritis Cartilage. 2015. PMID: 25600960 Free article.
Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NFкB-dependent pathway.
Guo B, Yang N, Borysiewicz E, Dudek M, Williams JL, Li J, Maywood ES, Adamson A, Hastings MH, Bateman JF, White MR, Boot-Handford RP, Meng QJ. Guo B, et al. Among authors: bateman jf. Osteoarthritis Cartilage. 2015 Nov;23(11):1981-8. doi: 10.1016/j.joca.2015.02.020. Osteoarthritis Cartilage. 2015. PMID: 26521744 Free PMC article.
The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration.
Dudek M, Yang N, Ruckshanthi JP, Williams J, Borysiewicz E, Wang P, Adamson A, Li J, Bateman JF, White MR, Boot-Handford RP, Hoyland JA, Meng QJ. Dudek M, et al. Among authors: bateman jf. Ann Rheum Dis. 2017 Mar;76(3):576-584. doi: 10.1136/annrheumdis-2016-209428. Epub 2016 Aug 3. Ann Rheum Dis. 2017. PMID: 27489225 Free PMC article.
211 results