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The NQO1 bioactivatable drug, β-lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism.
Silvers MA, Deja S, Singh N, Egnatchik RA, Sudderth J, Luo X, Beg MS, Burgess SC, DeBerardinis RJ, Boothman DA, Merritt ME. Silvers MA, et al. Among authors: singh n. J Biol Chem. 2017 Nov 3;292(44):18203-18216. doi: 10.1074/jbc.M117.813923. Epub 2017 Sep 15. J Biol Chem. 2017. PMID: 28916726 Free PMC article.
Modulators of Redox Metabolism in Head and Neck Cancer.
Chen X, Mims J, Huang X, Singh N, Motea E, Planchon SM, Beg M, Tsang AW, Porosnicu M, Kemp ML, Boothman DA, Furdui CM. Chen X, et al. Among authors: singh n. Antioxid Redox Signal. 2018 Dec 1;29(16):1660-1690. doi: 10.1089/ars.2017.7423. Epub 2017 Dec 20. Antioxid Redox Signal. 2018. PMID: 29113454 Free PMC article. Review.
Following anticancer drug activity in cell lysates with DNA devices.
Kahanda D, Singh N, Boothman DA, Slinker JD. Kahanda D, et al. Among authors: singh n. Biosens Bioelectron. 2018 Nov 15;119:1-9. doi: 10.1016/j.bios.2018.07.059. Epub 2018 Jul 30. Biosens Bioelectron. 2018. PMID: 30098460 Free PMC article.
Targeting NAD+ Metabolism to Enhance Radiation Therapy Responses.
Lewis JE, Singh N, Holmila RJ, Sumer BD, Williams NS, Furdui CM, Kemp ML, Boothman DA. Lewis JE, et al. Among authors: singh n. Semin Radiat Oncol. 2019 Jan;29(1):6-15. doi: 10.1016/j.semradonc.2018.10.009. Semin Radiat Oncol. 2019. PMID: 30573185 Free PMC article. Review.
NQO1-dependent, Tumor-selective Radiosensitization of Non-small Cell Lung Cancers.
Motea EA, Huang X, Singh N, Kilgore JA, Williams NS, Xie XJ, Gerber DE, Beg MS, Bey EA, Boothman DA. Motea EA, et al. Among authors: singh n. Clin Cancer Res. 2019 Apr 15;25(8):2601-2609. doi: 10.1158/1078-0432.CCR-18-2560. Epub 2019 Jan 7. Clin Cancer Res. 2019. PMID: 30617135 Free PMC article.
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