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PI3Kγ ablation does not promote diabetes in db/db mice, but improves insulin sensitivity and reduces pancreatic β-cell apoptosis.
Breasson L, Sardi C, Becattini B, Zani F, Solinas G. Breasson L, et al. Among authors: becattini b. FASEB J. 2018 Jan;32(1):319-329. doi: 10.1096/fj.201700372RR. Epub 2017 Sep 13. FASEB J. 2018. PMID: 28904022
We conclude that PI3Kgamma inhibition in obese patients who are predisposed to beta-cell failure is not expected to produce adverse effects on insulin secretion.-Breasson, L., Sardi, C., Becattini, B., Zani, F., Solinas, G. PI3Kgamma ablation does not promote diabet …
We conclude that PI3Kgamma inhibition in obese patients who are predisposed to beta-cell failure is not expected to produce adverse effects …
JNK1 ablation in mice confers long-term metabolic protection from diet-induced obesity at the cost of moderate skin oxidative damage.
Becattini B, Zani F, Breasson L, Sardi C, D'Agostino VG, Choo MK, Provenzani A, Park JM, Solinas G. Becattini B, et al. FASEB J. 2016 Sep;30(9):3124-32. doi: 10.1096/fj.201600393R. Epub 2016 May 26. FASEB J. 2016. PMID: 27230858 Free PMC article.
We conclude that compounds targeting JNK1 activity in brain and adipose tissue, which do not accumulate in the skin, may be safer and most effective.-Becattini, B., Zani, F., Breasson, L., Sardi, C., D'Agostino, V. G., Choo, M.-K., Provenzani, A., Park, J. ...
We conclude that compounds targeting JNK1 activity in brain and adipose tissue, which do not accumulate in the skin, may be safer and most e …
The role of PI3Kγ in metabolism and macrophage activation.
Solinas G, Becattini B. Solinas G, et al. Among authors: becattini b. Oncotarget. 2017 Oct 25;8(63):106145-106146. doi: 10.18632/oncotarget.22068. eCollection 2017 Dec 5. Oncotarget. 2017. PMID: 29290924 Free PMC article. No abstract available.
29 results