Pearson PG - Search Results

1

Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase Inhibitor with a Differentiated Selectivity and In Vivo Potency Profile.

Barf T, Covey T, Izumi R, van de Kar B, Gulrajani M, van Lith B, van Hoek M, de Zwart E, Mittag D, Demont D, Verkaik S, Krantz F, Pearson PG, Ulrich R, Kaptein A. Barf T, et al. Among authors: pearson pg. J Pharmacol Exp Ther. 2017 Nov;363(2):240-252. doi: 10.1124/jpet.117.242909. Epub 2017 Sep 7. J Pharmacol Exp Ther. 2017. PMID: 28882879

2

Bioavailability, Biotransformation, and Excretion of the Covalent Bruton Tyrosine Kinase Inhibitor Acalabrutinib in Rats, Dogs, and Humans.

Podoll T, Pearson PG, Evarts J, Ingallinera T, Bibikova E, Sun H, Gohdes M, Cardinal K, Sanghvi M, Slatter JG. Podoll T, et al. Among authors: pearson pg. Drug Metab Dispos. 2019 Feb;47(2):145-154. doi: 10.1124/dmd.118.084459. Epub 2018 Nov 15. Drug Metab Dispos. 2019. PMID: 30442651 Clinical Trial.

3

Pharmacokinetics and interactions of a novel antagonist of chemokine receptor 5 (CCR5) with ritonavir in rats and monkeys: role of CYP3A and P-glycoprotein.

Kumar S, Kwei GY, Poon GK, Iliff SA, Wang Y, Chen Q, Franklin RB, Didolkar V, Wang RW, Yamazaki M, Chiu SH, Lin JH, Pearson PG, Baillie TA. Kumar S, et al. Among authors: pearson pg. J Pharmacol Exp Ther. 2003 Mar;304(3):1161-71. doi: 10.1124/jpet.102.045096. J Pharmacol Exp Ther. 2003. PMID: 12604693

4

Mechanistic studies on metabolic interactions between gemfibrozil and statins.

Prueksaritanont T, Zhao JJ, Ma B, Roadcap BA, Tang C, Qiu Y, Liu L, Lin JH, Pearson PG, Baillie TA. Prueksaritanont T, et al. Among authors: pearson pg. J Pharmacol Exp Ther. 2002 Jun;301(3):1042-51. doi: 10.1124/jpet.301.3.1042. J Pharmacol Exp Ther. 2002. PMID: 12023536

5

Biotransformation of tirilazad in human: 3. tirilazad A-ring reduction by human liver microsomal 5alpha-reductase type 1 and type 2.

Wienkers LC, Steenwyk RC, Hauer MJ, Fleishaker JC, Pearson PG. Wienkers LC, et al. Among authors: pearson pg. J Pharmacol Exp Ther. 1998 Nov;287(2):583-90. J Pharmacol Exp Ther. 1998. PMID: 9808684

6

An inhibitory metabolite leads to dose- and time-dependent pharmacokinetics of (R)-N-{1-[3-(4-ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in human subjects after multiple dosing.

Tonn GR, Wong SG, Wong SC, Johnson MG, Ma J, Cho R, Floren LC, Kersey K, Berry K, Marcus AP, Wang X, Van Lengerich B, Medina JC, Pearson PG, Wong BK. Tonn GR, et al. Among authors: pearson pg. Drug Metab Dispos. 2009 Mar;37(3):502-13. doi: 10.1124/dmd.108.021931. Epub 2008 Dec 16. Drug Metab Dispos. 2009. PMID: 19088267 Clinical Trial.

7

Biotransformation of methyl isocyanate in the rat. Evidence for glutathione conjugation as a major pathway of metabolism and implications for isocyanate-mediated toxicities.

Slatter JG, Rashed MS, Pearson PG, Han DH, Baillie TA. Slatter JG, et al. Among authors: pearson pg. Chem Res Toxicol. 1991 Mar-Apr;4(2):157-61. doi: 10.1021/tx00020a006. Chem Res Toxicol. 1991. PMID: 1782345

8

Carbamoylation of peptides and proteins in vitro by S-(N-methylcarbamoyl)glutathione and S-(N-methylcarbamoyl)cysteine, two electrophilic S-linked conjugates of methyl isocyanate.

Pearson PG, Slatter JG, Rashed MS, Han DH, Baillie TA. Pearson PG, et al. Chem Res Toxicol. 1991 Jul-Aug;4(4):436-44. doi: 10.1021/tx00022a007. Chem Res Toxicol. 1991. PMID: 1912331

9

Metabolism and pharmacokinetics of a dipeptidyl peptidase IV inhibitor in rats, dogs, and monkeys with selective carbamoyl glucuronidation of the primary amine in dogs.

Beconi MG, Mao A, Liu DQ, Kochansky C, Pereira T, Raab C, Pearson P, Lee Chiu SH. Beconi MG, et al. Drug Metab Dispos. 2003 Oct;31(10):1269-77. doi: 10.1124/dmd.31.10.1269. Drug Metab Dispos. 2003. PMID: 12975337

10

Comparative pharmacokinetics and pharmacodynamics of the advanced Retinol-Binding Protein 4 antagonist in dog and cynomolgus monkey.

Racz B, Varadi A, Pearson PG, Petrukhin K. Racz B, et al. Among authors: pearson pg. PLoS One. 2020 Jan 24;15(1):e0228291. doi: 10.1371/journal.pone.0228291. eCollection 2020. PLoS One. 2020. PMID: 31978148 Free PMC article.

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