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Pathogenic CANVAS (AAGGG)n repeats stall DNA replication due to the formation of alternative DNA structures.
Hisey JA, Radchenko EA, Ceschi S, Rastokina A, Mandel NH, McGinty RJ, Matos-Rodrigues G, Hernandez A, Nussenzweig A, Mirkin SM. Hisey JA, et al. bioRxiv [Preprint]. 2023 Jul 26:2023.07.25.550509. doi: 10.1101/2023.07.25.550509. bioRxiv. 2023. Update in: Nucleic Acids Res. 2024 May 8;52(8):4361-4374. doi: 10.1093/nar/gkae124 PMID: 37546920 Free PMC article. Updated. Preprint.