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A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias In Vivo.
Nguyen HA, Su Y, Zhang JY, Antanasijevic A, Caffrey M, Schalk AM, Liu L, Rondelli D, Oh A, Mahmud DL, Bosland MC, Kajdacsy-Balla A, Peirs S, Lammens T, Mondelaers V, De Moerloose B, Goossens S, Schlicht MJ, Kabirov KK, Lyubimov AV, Merrill BJ, Saunthararajah Y, Van Vlierberghe P, Lavie A. Nguyen HA, et al. Among authors: schalk am. Cancer Res. 2018 Mar 15;78(6):1549-1560. doi: 10.1158/0008-5472.CAN-17-2106. Epub 2018 Jan 17. Cancer Res. 2018. PMID: 29343523 Free PMC article.
In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia.
Van Trimpont M, Schalk AM, De Visser Y, Nguyen HA, Reunes L, Vandemeulebroecke K, Peeters E, Su Y, Lee H, Lorenzi PL, Chan WK, Mondelaers V, De Moerloose B, Lammens T, Goossens S, Van Vlierberghe P, Lavie A. Van Trimpont M, et al. Among authors: schalk am. Haematologica. 2023 Feb 1;108(2):409-419. doi: 10.3324/haematol.2022.281390. Haematologica. 2023. PMID: 35979719 Free PMC article.
A human-like glutaminase-free asparaginase is highly efficacious in ASNSlow leukemia and solid cancer mouse xenograft models.
Van Trimpont M, Schalk AM, Hofkens K, Peeters E, T'Sas S, Vandemeulebroecke K, Su Y, De Loera A, Garcia A, Chen H, Lammens T, Van Vlierberghe P, Goossens S, Lavie A. Van Trimpont M, et al. Among authors: schalk am. Cancer Lett. 2024 Dec 19;611:217404. doi: 10.1016/j.canlet.2024.217404. Online ahead of print. Cancer Lett. 2024. PMID: 39709177 Free article.
Crystal structure of the Rab33B/Atg16L1 effector complex.
Metje-Sprink J, Groffmann J, Neumann P, Barg-Kues B, Ficner R, Kühnel K, Schalk AM, Binotti B. Metje-Sprink J, et al. Among authors: schalk am. Sci Rep. 2020 Jul 31;10(1):12956. doi: 10.1038/s41598-020-69637-0. Sci Rep. 2020. PMID: 32737358 Free PMC article.
The GTPase Rab26 links synaptic vesicles to the autophagy pathway.
Binotti B, Pavlos NJ, Riedel D, Wenzel D, Vorbrüggen G, Schalk AM, Kühnel K, Boyken J, Erck C, Martens H, Chua JJ, Jahn R. Binotti B, et al. Among authors: schalk am. Elife. 2015 Feb 2;4:e05597. doi: 10.7554/eLife.05597. Elife. 2015. PMID: 25643395 Free PMC article.
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