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Knockout of the murine cysteine dioxygenase gene results in severe impairment in ability to synthesize taurine and an increased catabolism of cysteine to hydrogen sulfide.
Ueki I, Roman HB, Valli A, Fieselmann K, Lam J, Peters R, Hirschberger LL, Stipanuk MH. Ueki I, et al. Among authors: stipanuk mh. Am J Physiol Endocrinol Metab. 2011 Oct;301(4):E668-84. doi: 10.1152/ajpendo.00151.2011. Epub 2011 Jun 21. Am J Physiol Endocrinol Metab. 2011. PMID: 21693692 Free PMC article.
Primary hepatocytes from mice lacking cysteine dioxygenase show increased cysteine concentrations and higher rates of metabolism of cysteine to hydrogen sulfide and thiosulfate.
Jurkowska H, Roman HB, Hirschberger LL, Sasakura K, Nagano T, Hanaoka K, Krijt J, Stipanuk MH. Jurkowska H, et al. Among authors: stipanuk mh. Amino Acids. 2014 May;46(5):1353-65. doi: 10.1007/s00726-014-1700-8. Epub 2014 Mar 8. Amino Acids. 2014. PMID: 24609271 Free PMC article.
106 results