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A natively paired antibody library yields drug leads with higher sensitivity and specificity than a randomly paired antibody library.
Adler AS, Bedinger D, Adams MS, Asensio MA, Edgar RC, Leong R, Leong J, Mizrahi RA, Spindler MJ, Bandi SR, Huang H, Tawde P, Brams P, Johnson DS. Adler AS, et al. Among authors: leong j, leong r. MAbs. 2018 Apr;10(3):431-443. doi: 10.1080/19420862.2018.1426422. Epub 2018 Feb 1. MAbs. 2018. PMID: 29376776 Free PMC article.
Preferential Identification of Agonistic OX40 Antibodies by Using Cell Lysate to Pan Natively Paired, Humanized Mouse-Derived Yeast Surface Display Libraries.
Medina-Cucurella AV, Mizrahi RA, Asensio MA, Edgar RC, Leong J, Leong R, Lim YW, Nelson A, Niedecken AR, Simons JF, Spindler MJ, Stadtmiller K, Wayham N, Adler AS, Johnson DS. Medina-Cucurella AV, et al. Among authors: leong j, leong r. Antibodies (Basel). 2019 Feb 19;8(1):17. doi: 10.3390/antib8010017. Antibodies (Basel). 2019. PMID: 31544823 Free PMC article.
Generation of recombinant hyperimmune globulins from diverse B-cell repertoires.
Keating SM, Mizrahi RA, Adams MS, Asensio MA, Benzie E, Carter KP, Chiang Y, Edgar RC, Gautam BK, Gras A, Leong J, Leong R, Lim YW, Manickam VA, Medina-Cucurella AV, Niedecken AR, Saini J, Simons JF, Spindler MJ, Stadtmiller K, Tinsley B, Wagner EK, Wayham N, Tracy L, Lundberg CV, Büscher D, Terencio JV, Roalfe L, Pearce E, Richardson H, Goldblatt D, Ramjag AT, Carrington CVF, Simmons G, Muench MO, Chamow SM, Monroe B, Olson C, Oguin TH, Lynch H, Jeanfreau R, Mosher RA, Walch MJ, Bartley CR, Ross CA, Meyer EH, Adler AS, Johnson DS. Keating SM, et al. Among authors: leong j, leong r. Nat Biotechnol. 2021 Aug;39(8):989-999. doi: 10.1038/s41587-021-00894-8. Epub 2021 Apr 15. Nat Biotechnol. 2021. PMID: 33859400 Free PMC article.
GMP Manufacturing and IND-Enabling Studies of a Recombinant Hyperimmune Globulin Targeting SARS-CoV-2.
Mizrahi RA, Lin WY, Gras A, Niedecken AR, Wagner EK, Keating SM, Ikon N, Manickam VA, Asensio MA, Leong J, Medina-Cucurella AV, Benzie E, Carter KP, Chiang Y, Edgar RC, Leong R, Lim YW, Simons JF, Spindler MJ, Stadtmiller K, Wayham N, Büscher D, Terencio JV, Germanio CD, Chamow SM, Olson C, Pino PA, Park JG, Hicks A, Ye C, Garcia-Vilanova A, Martinez-Sobrido L, Torrelles JB, Johnson DS, Adler AS. Mizrahi RA, et al. Among authors: leong j, leong r. Pathogens. 2022 Jul 19;11(7):806. doi: 10.3390/pathogens11070806. Pathogens. 2022. PMID: 35890050 Free PMC article.
Upadacitinib induction is effective and safe in ulcerative colitis patients including those with prior exposure to tofacitinib: a multicenter real-world cohort study.
Gilmore R, Fernandes R, Hartley I, Arzivian A, Leong R, Andrew B, Vasudevan A, Greeve T, Moore GT, Kim S, Lightowler D, Singh A, Mahy G, Mithanthaya A, Venugopaul K, Han S, Bryant R, West J, Segal J, Christensen B, Corte C, Ding N, An YK, Begun J. Gilmore R, et al. Among authors: leong r. Intest Res. 2024 Dec 20. doi: 10.5217/ir.2024.00127. Online ahead of print. Intest Res. 2024. PMID: 39709985 Free article.
Patient-Reported Outcomes for Low-Risk Ductal Carcinoma In Situ: A Secondary Analysis of the COMET Randomized Clinical Trial.
Partridge AH, Hyslop T, Rosenberg SM, Bennett AV, Drier S, Jonsson M, Shimada A, Li Y, Li Y, Lynch T, Frank E, Collyar D, Basila D, Pinto D, Weiss A, Wolf A, Norris K, Witten M, Boisvert M, Giuliano A, Larson KE, Yost K, McAuliffe PF, Krie A, Tamirisa N, Darai S, Carey L, Thompson A, Hwang ES; COMET Study Consortium. Partridge AH, et al. JAMA Oncol. 2024 Dec 12. doi: 10.1001/jamaoncol.2024.6556. Online ahead of print. JAMA Oncol. 2024. PMID: 39665588
Active Monitoring With or Without Endocrine Therapy for Low-Risk Ductal Carcinoma In Situ: The COMET Randomized Clinical Trial.
Hwang ES, Hyslop T, Lynch T, Ryser MD, Weiss A, Wolf A, Norris K, Witten M, Grimm L, Schnitt S, Badve S, Factor R, Frank E, Collyar D, Basila D, Pinto D, Watson MA, West R, Davies L, Donovan JL, Shimada A, Li Y, Li Y, Bennett AV, Rosenberg S, Marks J, Winer E, Boisvert M, Giuliano A, Larson KE, Yost K, McAuliffe PF, Krie A, Tamirisa N, Carey LA, Thompson AM, Partridge AH; COMET Study Investigators. Hwang ES, et al. JAMA. 2024 Dec 12. doi: 10.1001/jama.2024.26698. Online ahead of print. JAMA. 2024. PMID: 39665585
472 results