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Page 1
Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification.
Widjaja CE, Olvera JG, Metz PJ, Phan AT, Savas JN, de Bruin G, Leestemaker Y, Berkers CR, de Jong A, Florea BI, Fisch K, Lopez J, Kim SH, Garcia DA, Searles S, Bui JD, Chang AN, Yates JR 3rd, Goldrath AW, Overkleeft HS, Ovaa H, Chang JT. Widjaja CE, et al. Among authors: savas jn. J Clin Invest. 2017 Oct 2;127(10):3609-3623. doi: 10.1172/JCI90895. Epub 2017 Aug 28. J Clin Invest. 2017. PMID: 28846070 Free PMC article.
Derailed protein turnover in the aging mammalian brain.
Rao NR, Upadhyay A, Savas JN. Rao NR, et al. Among authors: savas jn. Mol Syst Biol. 2024 Feb;20(2):120-139. doi: 10.1038/s44320-023-00009-2. Epub 2024 Jan 5. Mol Syst Biol. 2024. PMID: 38182797 Free PMC article.
Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.
Forrest MP, Dos Santos M, Piguel NH, Wang YZ, Hawkins NA, Bagchi VA, Dionisio LE, Yoon S, Simkin D, Martin-de-Saavedra MD, Gao R, Horan KE, George AL Jr, LeDoux MS, Kearney JA, Savas JN, Penzes P. Forrest MP, et al. Among authors: savas jn. Nat Commun. 2023 Feb 17;14(1):825. doi: 10.1038/s41467-023-36087-x. Nat Commun. 2023. PMID: 36808153 Free PMC article.
LRRTM2 interacts with Neurexin1 and regulates excitatory synapse formation.
de Wit J, Sylwestrak E, O'Sullivan ML, Otto S, Tiglio K, Savas JN, Yates JR 3rd, Comoletti D, Taylor P, Ghosh A. de Wit J, et al. Among authors: savas jn. Neuron. 2009 Dec 24;64(6):799-806. doi: 10.1016/j.neuron.2009.12.019. Neuron. 2009. PMID: 20064388 Free PMC article.
Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins.
Pham E, Crews L, Ubhi K, Hansen L, Adame A, Cartier A, Salmon D, Galasko D, Michael S, Savas JN, Yates JR, Glabe C, Masliah E. Pham E, et al. Among authors: savas jn. FEBS J. 2010 Jul;277(14):3051-67. doi: 10.1111/j.1742-4658.2010.07719.x. Epub 2010 Jun 22. FEBS J. 2010. PMID: 20573181 Free PMC article.
Mass spectrometry accelerates membrane protein analysis.
Savas JN, Stein BD, Wu CC, Yates JR 3rd. Savas JN, et al. Trends Biochem Sci. 2011 Jul;36(7):388-96. doi: 10.1016/j.tibs.2011.04.005. Epub 2011 May 26. Trends Biochem Sci. 2011. PMID: 21616670 Free PMC article. Review.
110 results