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Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial.
Gonem S, Berair R, Singapuri A, Hartley R, Laurencin MFM, Bacher G, Holzhauer B, Bourne M, Mistry V, Pavord ID, Mansur AH, Wardlaw AJ, Siddiqui SH, Kay RA, Brightling CE. Gonem S, et al. Among authors: kay ra. Lancet Respir Med. 2016 Sep;4(9):699-707. doi: 10.1016/S2213-2600(16)30179-5. Epub 2016 Aug 5. Lancet Respir Med. 2016. PMID: 27503237 Clinical Trial.
DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment.
Saunders R, Kaul H, Berair R, Gonem S, Singapuri A, Sutcliffe AJ, Chachi L, Biddle MS, Kaur D, Bourne M, Pavord ID, Wardlaw AJ, Siddiqui SH, Kay RA, Brook BS, Smallwood RH, Brightling CE. Saunders R, et al. Among authors: kay ra. Sci Transl Med. 2019 Feb 13;11(479):eaao6451. doi: 10.1126/scitranslmed.aao6451. Sci Transl Med. 2019. PMID: 30760581 Free article. Clinical Trial.
Relationship between lung function and quantitative computed tomographic parameters of airway remodeling, air trapping, and emphysema in patients with asthma and chronic obstructive pulmonary disease: A single-center study.
Hartley RA, Barker BL, Newby C, Pakkal M, Baldi S, Kajekar R, Kay R, Laurencin M, Marshall RP, Sousa AR, Parmar H, Siddiqui S, Gupta S, Brightling CE. Hartley RA, et al. Among authors: kay r. J Allergy Clin Immunol. 2016 May;137(5):1413-1422.e12. doi: 10.1016/j.jaci.2016.02.001. Epub 2016 Mar 19. J Allergy Clin Immunol. 2016. PMID: 27006248 Free PMC article.
30 results