Laufer SA - Search Results

1

Design, Synthesis, and Biological Evaluation of Novel Type I¹/₂ p38α MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine.

Walter NM, Wentsch HK, Bührmann M, Bauer SM, Döring E, Mayer-Wrangowski S, Sievers-Engler A, Willemsen-Seegers N, Zaman G, Buijsman R, Lämmerhofer M, Rauh D, Laufer SA. Walter NM, et al. Among authors: laufer sa. J Med Chem. 2017 Oct 12;60(19):8027-8054. doi: 10.1021/acs.jmedchem.7b00745. Epub 2017 Sep 7. J Med Chem. 2017. PMID: 28834431

2

From imidazoles to pyrimidines: new inhibitors of cytokine release.

Laufer SA, Wagner GK. Laufer SA, et al. J Med Chem. 2002 Jun 20;45(13):2733-40. doi: 10.1021/jm011098a. J Med Chem. 2002. PMID: 12061876

3

Imidazole inhibitors of cytokine release: probing substituents in the 2 position.

Laufer SA, Striegel HG, Wagner GK. Laufer SA, et al. J Med Chem. 2002 Oct 10;45(21):4695-705. doi: 10.1021/jm020873z. J Med Chem. 2002. PMID: 12361396

4

Identification of regioisomers in a series of N-substituted pyridin-4-yl imidazole derivatives by regiospecific synthesis, GC/MS, and 1H NMR.

Wagner GK, Kotschenreuther D, Zimmermann W, Laufer SA. Wagner GK, et al. Among authors: laufer sa. J Org Chem. 2003 May 30;68(11):4527-30. doi: 10.1021/jo026619w. J Org Chem. 2003. PMID: 12762762

5

Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes.

Laufer SA, Wagner GK, Kotschenreuther DA, Albrecht W. Laufer SA, et al. J Med Chem. 2003 Jul 17;46(15):3230-44. doi: 10.1021/jm030766k. J Med Chem. 2003. PMID: 12852754

6

Tetrasubstituted imidazole inhibitors of cytokine release: probing substituents in the N-1 position.

Laufer SA, Zimmermann W, Ruff KJ. Laufer SA, et al. J Med Chem. 2004 Dec 2;47(25):6311-25. doi: 10.1021/jm0496584. J Med Chem. 2004. PMID: 15566301

7

Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors.

Laufer SA, Domeyer DM, Scior TR, Albrecht W, Hauser DR. Laufer SA, et al. J Med Chem. 2005 Feb 10;48(3):710-22. doi: 10.1021/jm0408767. J Med Chem. 2005. PMID: 15689155

8

Sesquiterpene lactones as inhibitors of IL-8 expression in HeLa cells.

Lindenmeyer MT, Hrenn A, Kern C, Castro V, Murillo R, Müller S, Laufer S, Schulte-Mönting J, Siedle B, Merfort I. Lindenmeyer MT, et al. Bioorg Med Chem. 2006 Apr 15;14(8):2487-97. doi: 10.1016/j.bmc.2005.11.027. Epub 2005 Dec 1. Bioorg Med Chem. 2006. PMID: 16326104

9

New approaches to the treatment of inflammatory disorders small molecule inhibitors of p38 MAP kinase.

Peifer C, Wagner G, Laufer S. Peifer C, et al. Curr Top Med Chem. 2006;6(2):113-49. doi: 10.2174/156802606775270323. Curr Top Med Chem. 2006. PMID: 16454763 Review.

10

Substituted isoxazoles as potent inhibitors of p38 MAP kinase.

Laufer SA, Margutti S, Fritz MD. Laufer SA, et al. ChemMedChem. 2006 Feb;1(2):197-207. doi: 10.1002/cmdc.200500025. ChemMedChem. 2006. PMID: 16892352

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