Patel N - Search Results

1

In Silico Modeling Approach for the Evaluation of Gastrointestinal Dissolution, Supersaturation, and Precipitation of Posaconazole.

Hens B, Pathak SM, Mitra A, Patel N, Liu B, Patel S, Jamei M, Brouwers J, Augustijns P, Turner DB. Hens B, et al. Among authors: patel n, patel s. Mol Pharm. 2017 Dec 4;14(12):4321-4333. doi: 10.1021/acs.molpharmaceut.7b00396. Epub 2017 Sep 5. Mol Pharm. 2017. PMID: 28817288

2

Prediction of concentration-time profile and its inter-individual variability following the dermal drug absorption.

Polak S, Ghobadi C, Mishra H, Ahamadi M, Patel N, Jamei M, Rostami-Hodjegan A. Polak S, et al. Among authors: patel n. J Pharm Sci. 2012 Jul;101(7):2584-95. doi: 10.1002/jps.23155. Epub 2012 Apr 19. J Pharm Sci. 2012. PMID: 22517028

3

Quantitative prediction of formulation-specific food effects and their population variability from in vitro data with the physiologically-based ADAM model: a case study using the BCS/BDDCS Class II drug nifedipine.

Patel N, Polak S, Jamei M, Rostami-Hodjegan A, Turner DB. Patel N, et al. Eur J Pharm Sci. 2014 Jun 16;57:240-9. doi: 10.1016/j.ejps.2013.09.006. Epub 2013 Sep 21. Eur J Pharm Sci. 2014. PMID: 24060671

4

Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability.

Chetty M, Rose RH, Abduljalil K, Patel N, Lu G, Cain T, Jamei M, Rostami-Hodjegan A. Chetty M, et al. Among authors: patel n. Front Pharmacol. 2014 Nov 26;5:258. doi: 10.3389/fphar.2014.00258. eCollection 2014. Front Pharmacol. 2014. PMID: 25505415 Free PMC article.

5

Differences in Food Effects for 2 Weak Bases With Similar BCS Drug-Related Properties: What Is Happening in the Intestinal Lumen?

Cristofoletti R, Patel N, Dressman JB. Cristofoletti R, et al. Among authors: patel n. J Pharm Sci. 2016 Sep;105(9):2712-2722. doi: 10.1016/j.xphs.2015.11.033. Epub 2016 Feb 23. J Pharm Sci. 2016. PMID: 26921120

6

Examining the Use of a Mechanistic Model to Generate an In Vivo/In Vitro Correlation: Journey Through a Thought Process.

Mistry B, Patel N, Jamei M, Rostami-Hodjegan A, Martinez MN. Mistry B, et al. Among authors: patel n. AAPS J. 2016 Sep;18(5):1144-1158. doi: 10.1208/s12248-016-9930-1. Epub 2016 Jun 16. AAPS J. 2016. PMID: 27312260 Clinical Trial.

7

Comment on "In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically-Based Absorption Models".

Turner DB, Liu B, Patel N, Pathak SM, Polak S, Jamei M, Dressman J, Rostami-Hodjegan A. Turner DB, et al. Among authors: patel n. Mol Pharm. 2017 Jan 3;14(1):336-339. doi: 10.1021/acs.molpharmaceut.6b00469. Epub 2016 Dec 16. Mol Pharm. 2017. PMID: 27392013 No abstract available.

8

Early assessment of proarrhythmic risk of drugs using the in vitro data and single-cell-based in silico models: proof of concept.

Abbasi M, Small BG, Patel N, Jamei M, Polak S. Abbasi M, et al. Among authors: patel n. Toxicol Mech Methods. 2017 Feb;27(2):88-99. doi: 10.1080/15376516.2016.1256460. Epub 2016 Nov 23. Toxicol Mech Methods. 2017. PMID: 27813448

9

Assessment of Bioequivalence of Weak Base Formulations Under Various Dosing Conditions Using Physiologically Based Pharmacokinetic Simulations in Virtual Populations. Case Examples: Ketoconazole and Posaconazole.

Cristofoletti R, Patel N, Dressman JB. Cristofoletti R, et al. Among authors: patel n. J Pharm Sci. 2017 Feb;106(2):560-569. doi: 10.1016/j.xphs.2016.10.008. Epub 2016 Nov 16. J Pharm Sci. 2017. PMID: 27865610

10

Model-Based Analysis of Biopharmaceutic Experiments To Improve Mechanistic Oral Absorption Modeling: An Integrated in Vitro in Vivo Extrapolation Perspective Using Ketoconazole as a Model Drug.

Pathak SM, Ruff A, Kostewicz ES, Patel N, Turner DB, Jamei M. Pathak SM, et al. Among authors: patel n. Mol Pharm. 2017 Dec 4;14(12):4305-4320. doi: 10.1021/acs.molpharmaceut.7b00406. Epub 2017 Aug 25. Mol Pharm. 2017. PMID: 28771009 Free article.

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