Bueters TJH - Search Results

1

Assessment of translational risk in drug research: Role of biomarker classification and mechanism-based PKPD concepts.

Visser SAG, Bueters TJH. Visser SAG, et al. Among authors: bueters tjh. Eur J Pharm Sci. 2017 Nov 15;109S:S72-S77. doi: 10.1016/j.ejps.2017.08.006. Epub 2017 Aug 13. Eur J Pharm Sci. 2017. PMID: 28811131 Review.

2

The virtue of translational PKPD modeling in drug discovery: selecting the right clinical candidate while sparing animal lives.

Bueters T, Ploeger BA, Visser SA. Bueters T, et al. Drug Discov Today. 2013 Sep;18(17-18):853-62. doi: 10.1016/j.drudis.2013.05.001. Epub 2013 May 9. Drug Discov Today. 2013. PMID: 23665277 Review.

3

Optimization of human dose prediction by using quantitative and translational pharmacology in drug discovery.

Bueters T, Gibson C, Visser SA. Bueters T, et al. Future Med Chem. 2015;7(17):2351-69. doi: 10.4155/fmc.15.143. Epub 2015 Nov 24. Future Med Chem. 2015. PMID: 26599348 Review.

4

Correct assessment of new compounds using in vivo screening models can reduce false positives.

Bueters TJ, Hoogstraate J, Visser SA. Bueters TJ, et al. Drug Discov Today. 2009 Jan;14(1-2):89-94. doi: 10.1016/j.drudis.2008.09.003. Epub 2008 Oct 22. Drug Discov Today. 2009. PMID: 18840543 Review.

5

In vivo and ex vivo inhibition of spinal nerve ligation-induced ectopic activity by sodium channel blockers correlate to in vitro inhibition of NaV1.7 and clinical efficacy: a pharmacokinetic-pharmacodynamic translational approach.

Kalezic I, Luo L, Lund PE, Eriksson AB, Bueters T, Visser SA. Kalezic I, et al. Pharm Res. 2013 May;30(5):1409-22. doi: 10.1007/s11095-013-0979-6. Epub 2013 Feb 1. Pharm Res. 2013. PMID: 23371514

6

Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles.

Sanders JM, Beshore DC, Culberson JC, Fells JI, Imbriglio JE, Gunaydin H, Haidle AM, Labroli M, Mattioni BE, Sciammetta N, Shipe WD, Sheridan RP, Suen LM, Verras A, Walji A, Joshi EM, Bueters T. Sanders JM, et al. J Med Chem. 2017 Aug 24;60(16):6771-6780. doi: 10.1021/acs.jmedchem.6b01577. Epub 2017 May 5. J Med Chem. 2017. PMID: 28418656 Review.

7

Can quantitative pharmacology improve productivity in pharmaceutical research and development?

Patel M, Bueters T. Patel M, et al. Expert Opin Drug Discov. 2020 Oct;15(10):1111-1114. doi: 10.1080/17460441.2020.1776257. Epub 2020 Jun 8. Expert Opin Drug Discov. 2020. PMID: 32511018 No abstract available.

8

Optimizing DMPK Properties: Experiences from a Big Pharma DMPK Department.

Sohlenius-Sternbeck AK, Janson J, Bylund J, Baranczewski P, Breitholtz-Emanuelsson A, Hu Y, Tsoi C, Lindgren A, Gissberg O, Bueters T, Briem S, Juric S, Johansson J, Bergh M, Hoogstraate J. Sohlenius-Sternbeck AK, et al. Curr Drug Metab. 2016;17(3):253-70. doi: 10.2174/1389200217666151210125637. Curr Drug Metab. 2016. PMID: 26651977 Review.

9

[No title available]

[No authors listed] [No authors listed] PMID: 31963044

10

3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models.

Macsari I, Besidski Y, Csjernyik G, Nilsson LI, Sandberg L, Yngve U, Ahlin K, Bueters T, Eriksson AB, Lund PE, Venyike E, Oerther S, Hygge Blakeman K, Luo L, Arvidsson PI. Macsari I, et al. J Med Chem. 2012 Aug 9;55(15):6866-80. doi: 10.1021/jm300623u. Epub 2012 Jul 23. J Med Chem. 2012. PMID: 22770500

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