A critical role for plasma kallikrein in the pathogenesis of autoantibody-induced arthritis.
Yang A, Zhou J, Wang B, Dai J, Colman RW, Song W, Wu Y.
Yang A, et al.
FASEB J. 2017 Dec;31(12):5419-5431. doi: 10.1096/fj.201700018R. Epub 2017 Aug 14.
FASEB J. 2017.
PMID: 28808141
Free PMC article.
Immune complex increased pKal activity, which led to HK cleavage. The absence of HK is associated with a decrease in joint vasopermeability. Thus, we identify a critical role for Kal in autoantibody-induced arthritis with pleiotropic effects, which suggests that it …
Immune complex increased pKal activity, which led to HK cleavage. The absence of HK is associated with a decrease in joint vasopermea …