Yan Y - Search Results

1

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.

Zhang P, Wang D, Zhao Y, Ren S, Gao K, Ye Z, Wang S, Pan CW, Zhu Y, Yan Y, Yang Y, Wu D, He Y, Zhang J, Lu D, Liu X, Yu L, Zhao S, Li Y, Lin D, Wang Y, Wang L, Chen Y, Sun Y, Wang C, Huang H. Zhang P, et al. Among authors: yan y. Nat Med. 2017 Sep;23(9):1055-1062. doi: 10.1038/nm.4379. Epub 2017 Aug 14. Nat Med. 2017. PMID: 28805822 Free PMC article.

2

Inhibiting histone deacetylases suppresses glucose metabolism and hepatocellular carcinoma growth by restoring FBP1 expression.

Yang J, Jin X, Yan Y, Shao Y, Pan Y, Roberts LR, Zhang J, Huang H, Jiang J. Yang J, et al. Among authors: yan y. Sci Rep. 2017 Mar 6;7:43864. doi: 10.1038/srep43864. Sci Rep. 2017. PMID: 28262837 Free PMC article.

3

Loss of FOXO1 Cooperates with TMPRSS2-ERG Overexpression to Promote Prostate Tumorigenesis and Cell Invasion.

Yang Y, Blee AM, Wang D, An J, Pan Y, Yan Y, Ma T, He Y, Dugdale J, Hou X, Zhang J, Weroha SJ, Zhu WG, Wang YA, DePinho RA, Xu W, Huang H. Yang Y, et al. Among authors: yan y. Cancer Res. 2017 Dec 1;77(23):6524-6537. doi: 10.1158/0008-5472.CAN-17-0686. Epub 2017 Oct 6. Cancer Res. 2017. PMID: 28986382 Free PMC article.

4

Dual inhibition of AKT-mTOR and AR signaling by targeting HDAC3 in PTEN- or SPOP-mutated prostate cancer.

Yan Y, An J, Yang Y, Wu D, Bai Y, Cao W, Ma L, Chen J, Yu Z, He Y, Jin X, Pan Y, Ma T, Wang S, Hou X, Weroha SJ, Karnes RJ, Zhang J, Westendorf JJ, Wang L, Chen Y, Xu W, Zhu R, Wang D, Huang H. Yan Y, et al. EMBO Mol Med. 2018 Apr;10(4):e8478. doi: 10.15252/emmm.201708478. EMBO Mol Med. 2018. PMID: 29523594 Free PMC article.

5

TMPRSS2-ERG Controls Luminal Epithelial Lineage and Antiandrogen Sensitivity in PTEN and TP53-Mutated Prostate Cancer.

Blee AM, He Y, Yang Y, Ye Z, Yan Y, Pan Y, Ma T, Dugdale J, Kuehn E, Kohli M, Jimenez R, Chen Y, Xu W, Wang L, Huang H. Blee AM, et al. Among authors: yan y. Clin Cancer Res. 2018 Sep 15;24(18):4551-4565. doi: 10.1158/1078-0432.CCR-18-0653. Epub 2018 May 29. Clin Cancer Res. 2018. PMID: 29844131 Free PMC article.

6

DUB3 Promotes BET Inhibitor Resistance and Cancer Progression by Deubiquitinating BRD4.

Jin X, Yan Y, Wang D, Ding D, Ma T, Ye Z, Jimenez R, Wang L, Wu H, Huang H. Jin X, et al. Among authors: yan y. Mol Cell. 2018 Aug 16;71(4):592-605.e4. doi: 10.1016/j.molcel.2018.06.036. Epub 2018 Jul 26. Mol Cell. 2018. PMID: 30057199 Free PMC article.

7

Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 Expression.

Jin X, Ding D, Yan Y, Li H, Wang B, Ma L, Ye Z, Ma T, Wu Q, Rodrigues DN, Kohli M, Jimenez R, Wang L, Goodrich DW, de Bono J, Dong H, Wu H, Zhu R, Huang H. Jin X, et al. Among authors: yan y. Mol Cell. 2019 Jan 3;73(1):22-35.e6. doi: 10.1016/j.molcel.2018.10.034. Epub 2018 Dec 6. Mol Cell. 2019. PMID: 30527665 Free PMC article.

8

RUNX2 overexpression and PTEN haploinsufficiency cooperate to promote CXCR7 expression and cellular trafficking, AKT hyperactivation and prostate tumorigenesis.

Bai Y, Yang Y, Yan Y, Zhong J, Blee AM, Pan Y, Ma T, Karnes RJ, Jimenez R, Xu W, Huang H. Bai Y, et al. Among authors: yan y. Theranostics. 2019 May 24;9(12):3459-3475. doi: 10.7150/thno.33292. eCollection 2019. Theranostics. 2019. PMID: 31281490 Free PMC article.

9

Overcoming EZH2 Inhibitor Resistance by Taxane in PTEN-Mutated Cancer.

Ma L, Yan Y, Bai Y, Yang Y, Pan Y, Gang X, Karnes RJ, Zhang J, Lv Q, Wu Q, Huang H. Ma L, et al. Among authors: yan y. Theranostics. 2019 Jul 9;9(17):5020-5034. doi: 10.7150/thno.34700. eCollection 2019. Theranostics. 2019. PMID: 31410199 Free PMC article.

10

The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer.

Yan Y, Ma J, Wang D, Lin D, Pang X, Wang S, Zhao Y, Shi L, Xue H, Pan Y, Zhang J, Wahlestedt C, Giles FJ, Chen Y, Gleave ME, Collins CC, Ye D, Wang Y, Huang H. Yan Y, et al. EMBO Mol Med. 2019 Nov 7;11(11):e10659. doi: 10.15252/emmm.201910659. Epub 2019 Sep 26. EMBO Mol Med. 2019. PMID: 31559706 Free PMC article.

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