Watt JM - Search Results

1

Direct Activation of NADPH Oxidase 2 by 2-Deoxyribose-1-Phosphate Triggers Nuclear Factor Kappa B-Dependent Angiogenesis.

Vara D, Watt JM, Fortunato TM, Mellor H, Burgess M, Wicks K, Mace K, Reeksting S, Lubben A, Wheeler-Jones CPD, Pula G. Vara D, et al. Among authors: watt jm. Antioxid Redox Signal. 2018 Jan 10;28(2):110-130. doi: 10.1089/ars.2016.6869. Epub 2017 Sep 18. Antioxid Redox Signal. 2018. PMID: 28793782 Free PMC article.

2

2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist.

Fliegert R, Bauche A, Wolf Pérez AM, Watt JM, Rozewitz MD, Winzer R, Janus M, Gu F, Rosche A, Harneit A, Flato M, Moreau C, Kirchberger T, Wolters V, Potter BVL, Guse AH. Fliegert R, et al. Among authors: watt jm. Nat Chem Biol. 2017 Sep;13(9):1036-1044. doi: 10.1038/nchembio.2415. Epub 2017 Jun 26. Nat Chem Biol. 2017. PMID: 28671679 Free PMC article.

3

Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy.

Kyratsous NI, Bauer IJ, Zhang G, Pesic M, Bartholomäus I, Mues M, Fang P, Wörner M, Everts S, Ellwart JW, Watt JM, Potter BVL, Hohlfeld R, Wekerle H, Kawakami N. Kyratsous NI, et al. Among authors: watt jm. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6381-E6389. doi: 10.1073/pnas.1701806114. Epub 2017 Jul 17. Proc Natl Acad Sci U S A. 2017. PMID: 28716943 Free PMC article.

4

Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349.

Fliegert R, Watt JM, Schöbel A, Rozewitz MD, Moreau C, Kirchberger T, Thomas MP, Sick W, Araujo AC, Harneit A, Potter BVL, Guse AH. Fliegert R, et al. Among authors: watt jm. Biochem J. 2017 Jun 16;474(13):2159-2175. doi: 10.1042/BCJ20170091. Biochem J. 2017. PMID: 28515263 Free PMC article.

5

Synthesis of Terminal Ribose Analogues of Adenosine 5'-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2.

Baszczyňski O, Watt JM, Rozewitz MD, Guse AH, Fliegert R, Potter BVL. Baszczyňski O, et al. Among authors: watt jm. J Org Chem. 2019 May 17;84(10):6143-6157. doi: 10.1021/acs.joc.9b00338. Epub 2019 May 7. J Org Chem. 2019. PMID: 30978018 Free PMC article.

6

Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid "L-cyclic inosine 5'-diphosphate ribose".

Watt JM, Graeff R, Thomas MP, Potter BVL. Watt JM, et al. Sci Rep. 2017 Nov 23;7(1):16100. doi: 10.1038/s41598-017-16388-0. Sci Rep. 2017. PMID: 29170518 Free PMC article.

7

Small Molecule Antagonists of NAADP-Induced Ca²⁺ Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease.

Zhang B, Watt JM, Cordiglieri C, Dammermann W, Mahon MF, Flügel A, Guse AH, Potter BVL. Zhang B, et al. Among authors: watt jm. Sci Rep. 2018 Nov 13;8(1):16775. doi: 10.1038/s41598-018-34917-3. Sci Rep. 2018. PMID: 30425261 Free PMC article.

8

Different substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR.

Kühn FJP, Watt JM, Potter BVL, Lückhoff A. Kühn FJP, et al. Among authors: watt jm. Sci Rep. 2019 Mar 21;9(1):4985. doi: 10.1038/s41598-019-41531-4. Sci Rep. 2019. PMID: 30899048 Free PMC article.

9

Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers.

Watt JM, Thomas MP, Potter BVL. Watt JM, et al. Sci Rep. 2018 Oct 15;8(1):15268. doi: 10.1038/s41598-018-33484-x. Sci Rep. 2018. PMID: 30323284 Free PMC article.

10

Synthesis of phosphonoacetate analogues of the second messenger adenosine 5'-diphosphate ribose (ADPR).

Baszczyňski O, Watt JM, Rozewitz MD, Fliegert R, Guse AH, Potter BVL. Baszczyňski O, et al. Among authors: watt jm. RSC Adv. 2020;10(3):1776-1785. doi: 10.1039/C9RA09284F. Epub 2020 Jan 9. RSC Adv. 2020. PMID: 31934327 Free PMC article.

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