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Identification of two novel mutations in RASGRP2 affecting platelet CalDAG-GEFI expression and function in patients with bleeding diathesis.
Sevivas T, Bastida JM, Paul DS, Caparros E, Palma-Barqueros V, Coucelo M, Marques D, Ferrer-Marín F, González-Porras JR, Vicente V, Hernández-Rivas JM, Watson SP, Lozano ML, Bergmeier W, Rivera J. Sevivas T, et al. Among authors: bergmeier w. Platelets. 2018 Mar;29(2):192-195. doi: 10.1080/09537104.2017.1336214. Epub 2017 Aug 1. Platelets. 2018. PMID: 28762304 Free PMC article.
CalDAG-GEFI and platelet activation.
Stefanini L, Bergmeier W. Stefanini L, et al. Among authors: bergmeier w. Platelets. 2010;21(4):239-43. doi: 10.3109/09537101003639931. Platelets. 2010. PMID: 20218908 Free PMC article. Review.
Rap1 and its effector RIAM are required for lymphocyte trafficking.
Su W, Wynne J, Pinheiro EM, Strazza M, Mor A, Montenont E, Berger J, Paul DS, Bergmeier W, Gertler FB, Philips MR. Su W, et al. Among authors: bergmeier w. Blood. 2015 Dec 17;126(25):2695-703. doi: 10.1182/blood-2015-05-644104. Epub 2015 Aug 31. Blood. 2015. PMID: 26324702 Free PMC article.
RAP1-GTPase signaling and platelet function.
Stefanini L, Bergmeier W. Stefanini L, et al. Among authors: bergmeier w. J Mol Med (Berl). 2016 Jan;94(1):13-9. doi: 10.1007/s00109-015-1346-3. Epub 2015 Oct 1. J Mol Med (Berl). 2016. PMID: 26423530 Free PMC article. Review.
CalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in Mice.
Boulaftali Y, Owens AP 3rd, Beale A, Piatt R, Casari C, Lee RH, Conley PB, Paul DS, Mackman N, Bergmeier W. Boulaftali Y, et al. Among authors: bergmeier w. Arterioscler Thromb Vasc Biol. 2016 May;36(5):792-9. doi: 10.1161/ATVBAHA.115.306347. Epub 2016 Mar 17. Arterioscler Thromb Vasc Biol. 2016. PMID: 26988592 Free PMC article.
Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction.
Lozano ML, Cook A, Bastida JM, Paul DS, Iruin G, Cid AR, Adan-Pedroso R, Ramón González-Porras J, Hernández-Rivas JM, Fletcher SJ, Johnson B, Morgan N, Ferrer-Marin F, Vicente V, Sondek J, Watson SP, Bergmeier W, Rivera J. Lozano ML, et al. Among authors: bergmeier w. Blood. 2016 Sep 1;128(9):1282-9. doi: 10.1182/blood-2015-11-683102. Epub 2016 May 27. Blood. 2016. PMID: 27235135 Free PMC article. Clinical Trial.
Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor.
Deng W, Xu Y, Chen W, Paul DS, Syed AK, Dragovich MA, Liang X, Zakas P, Berndt MC, Di Paola J, Ware J, Lanza F, Doering CB, Bergmeier W, Zhang XF, Li R. Deng W, et al. Among authors: bergmeier w. Nat Commun. 2016 Sep 27;7:12863. doi: 10.1038/ncomms12863. Nat Commun. 2016. PMID: 27670775 Free PMC article.
147 results