Kume M - Search Results

1

Discovery of orally bioavailable cyclohexanol-based NR2B-selective NMDA receptor antagonists with analgesic activity utilizing a scaffold hopping approach.

Anan K, Masui M, Hara S, Ohara M, Kume M, Yamamoto S, Shinohara S, Tsuji H, Shimada S, Yagi S, Hasebe N, Kai H. Anan K, et al. Among authors: kume m. Bioorg Med Chem Lett. 2017 Sep 1;27(17):4194-4198. doi: 10.1016/j.bmcl.2017.06.076. Epub 2017 Jul 5. Bioorg Med Chem Lett. 2017. PMID: 28754363

2

Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 1: Initial structure-activity relationship studies of a hit from a high throughput screening.

Tobinaga H, Kameyama T, Oohara M, Kobayashi N, Ohdan M, Ishizuka N, Kume M, Tomari M, Tanaka Y, Takahashi F, Kinoshita H, Shimada S, Shinohara S, Kai H. Tobinaga H, et al. Among authors: kume m. Bioorg Med Chem Lett. 2018 Jul 15;28(13):2338-2342. doi: 10.1016/j.bmcl.2017.04.060. Epub 2017 Apr 19. Bioorg Med Chem Lett. 2018. PMID: 29805055

3

Discovery of naldemedine: A potent and orally available opioid receptor antagonist for treatment of opioid-induced adverse effects.

Inagaki M, Kume M, Tamura Y, Hara S, Goto Y, Haga N, Hasegawa T, Nakamura T, Koike K, Oonishi S, Kanemasa T, Kai H. Inagaki M, et al. Among authors: kume m. Bioorg Med Chem Lett. 2019 Jan 1;29(1):73-77. doi: 10.1016/j.bmcl.2018.11.007. Epub 2018 Nov 7. Bioorg Med Chem Lett. 2019. PMID: 30446313

4

Discovery of NR2B-selective antagonists via scaffold hopping and pharmacokinetic profile optimization.

Anan K, Masui M, Tazawa A, Tomida M, Haga Y, Kume M, Yamamoto S, Shinohara S, Tsuji H, Shimada S, Yagi S, Hasebe N, Kai H. Anan K, et al. Among authors: kume m. Bioorg Med Chem Lett. 2019 May 1;29(9):1143-1147. doi: 10.1016/j.bmcl.2019.02.017. Epub 2019 Feb 15. Bioorg Med Chem Lett. 2019. PMID: 30833109

5

Orally active cephalosporins. III. Synthesis and structure-activity relationships of new 3-heterocyclicthiomethylthio-7 beta-[(Z)- 2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-cephem-4 -carboxylic acids.

Kume M, Kubota T, Kimura Y, Nakashimizu H, Motokawa K. Kume M, et al. J Antibiot (Tokyo). 1993 Feb;46(2):316-30. doi: 10.7164/antibiotics.46.316. J Antibiot (Tokyo). 1993. PMID: 8468248 Free article.

6

[Orally active cephalosporins. I. Synthesis and structure-activity relationships of 7 beta-[2-(R)-amino-2-phenylacetamido]-3-(1H- 1,2,3-triazol-4-yl)alkylthiomethyl-3-cephem-4-carboxylic acid and related compounds].

Kume M, Kubota T, Kimura Y, Nakashimizu H, Motokawa K. Kume M, et al. Yakugaku Zasshi. 1992 Sep;112(9):622-37. doi: 10.1248/yakushi1947.112.9_622. Yakugaku Zasshi. 1992. PMID: 1469610 Japanese.

7

Novel antibacterial macrolides: synthesis of 15-membered diolides.

Ohara T, Kume M, Narukawa Y, Motokawa K, Uotani K, Nakai H. Ohara T, et al. Among authors: kume m. J Org Chem. 2002 Dec 27;67(26):9146-52. doi: 10.1021/jo020458e. J Org Chem. 2002. PMID: 12492314

8

Orally active cephalosporins. II. Synthesis and structure-activity relationships of new 7 beta-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-cephalospori ns with 1,2,3-triazole in C-3 side chain.

Kume M, Kubota T, Kimura Y, Nakashimizu H, Motokawa K, Nakano M. Kume M, et al. J Antibiot (Tokyo). 1993 Jan;46(1):177-92. doi: 10.7164/antibiotics.46.177. J Antibiot (Tokyo). 1993. PMID: 8436551 Free article.

9

Orally active cephalosporins. IV. Synthesis, antibacterial activity and oral absorption of 3-(1H-1,2,3-triazol-4-yl)thiomethylthio-cephalosporins.

Kume M, Kubota T, Kimura Y, Nakashimizu H, Motokawa K. Kume M, et al. Chem Pharm Bull (Tokyo). 1993 Apr;41(4):758-62. doi: 10.1248/cpb.41.758. Chem Pharm Bull (Tokyo). 1993. PMID: 8508477

10

The 7alpha-methoxy substituent in cephem or oxacephem antibiotics enhances in vivo anti-Helicobacter felis activity in mice after oral administration.

Kobayashi Y, Doi M, Nagata H, Kubota T, Kume M, Murakami K. Kobayashi Y, et al. Among authors: kume m. J Antimicrob Chemother. 2000 Jun;45(6):807-11. doi: 10.1093/jac/45.6.807. J Antimicrob Chemother. 2000. PMID: 10837434

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