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Chronic reduction of insulin receptors in the ventromedial hypothalamus produces glucose intolerance and islet dysfunction in the absence of weight gain.
Paranjape SA, Chan O, Zhu W, Horblitt AM, Grillo CA, Wilson S, Reagan L, Sherwin RS. Paranjape SA, et al. Among authors: horblitt am. Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E978-83. doi: 10.1152/ajpendo.00304.2011. Epub 2011 Aug 9. Am J Physiol Endocrinol Metab. 2011. PMID: 21828334 Free PMC article.
Glucose prevents the fall in ventromedial hypothalamic GABA that is required for full activation of glucose counterregulatory responses during hypoglycemia.
Zhu W, Czyzyk D, Paranjape SA, Zhou L, Horblitt A, Szabó G, Seashore MR, Sherwin RS, Chan O. Zhu W, et al. Among authors: horblitt a. Am J Physiol Endocrinol Metab. 2010 May;298(5):E971-7. doi: 10.1152/ajpendo.00749.2009. Epub 2010 Feb 9. Am J Physiol Endocrinol Metab. 2010. PMID: 20304763 Free PMC article.