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High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4+ T cells in both mice and humans.
Manfrini N, Ricciardi S, Miluzio A, Fedeli M, Scagliola A, Gallo S, Brina D, Adler T, Busch DH, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Biffo S. Manfrini N, et al. Among authors: brina d. Dev Comp Immunol. 2017 Dec;77:69-76. doi: 10.1016/j.dci.2017.07.022. Epub 2017 Jul 22. Dev Comp Immunol. 2017. PMID: 28743432
JNK inhibition arrests cotranslational degradation.
Gandin V, Brina D, Marchisio PC, Biffo S. Gandin V, et al. Among authors: brina d. Biochim Biophys Acta. 2010 Jul;1803(7):826-31. doi: 10.1016/j.bbamcr.2010.03.016. Epub 2010 Mar 30. Biochim Biophys Acta. 2010. PMID: 20359507 Free article.
23 results