Groothuis GMM - Search Results

1

Anticancer Gold N-Heterocyclic Carbene Complexes: A Comparative in vitro and ex vivo Study.

Estrada-Ortiz N, Guarra F, de Graaf IAM, Marchetti L, de Jager MH, Groothuis GMM, Gabbiani C, Casini A. Estrada-Ortiz N, et al. Among authors: groothuis gmm. ChemMedChem. 2017 Sep 7;12(17):1429-1435. doi: 10.1002/cmdc.201700316. Epub 2017 Aug 29. ChemMedChem. 2017. PMID: 28741878 Free article.

2

Caffeine-based gold(I) N-heterocyclic carbenes as possible anticancer agents: synthesis and biological properties.

Bertrand B, Stefan L, Pirrotta M, Monchaud D, Bodio E, Richard P, Le Gendre P, Warmerdam E, de Jager MH, Groothuis GM, Picquet M, Casini A. Bertrand B, et al. Inorg Chem. 2014 Feb 17;53(4):2296-303. doi: 10.1021/ic403011h. Epub 2014 Feb 5. Inorg Chem. 2014. PMID: 24499428

3

Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies.

de Graaf IA, Olinga P, de Jager MH, Merema MT, de Kanter R, van de Kerkhof EG, Groothuis GM. de Graaf IA, et al. Nat Protoc. 2010 Sep;5(9):1540-51. doi: 10.1038/nprot.2010.111. Epub 2010 Aug 19. Nat Protoc. 2010. PMID: 20725069

4

Precision-cut intestinal slices as in vitro tool for studies on drug metabolism.

Groothuis GM, de Graaf IA. Groothuis GM, et al. Curr Drug Metab. 2013 Jan;14(1):112-9. Curr Drug Metab. 2013. PMID: 22497569 Review.

5

Rat precision-cut intestinal slices to study P-gp activity and the potency of its inhibitors ex vivo.

Li M, de Graaf IA, de Jager MH, Groothuis GM. Li M, et al. Toxicol In Vitro. 2015 Aug;29(5):1070-8. doi: 10.1016/j.tiv.2015.04.011. Epub 2015 Apr 25. Toxicol In Vitro. 2015. PMID: 25917215

6

Precision-cut intestinal slices: alternative model for drug transport, metabolism, and toxicology research.

Li M, de Graaf IA, Groothuis GM. Li M, et al. Expert Opin Drug Metab Toxicol. 2016;12(2):175-90. doi: 10.1517/17425255.2016.1125882. Epub 2016 Jan 9. Expert Opin Drug Metab Toxicol. 2016. PMID: 26750630 Free article. Review.

7

P-gp activity and inhibition in the different regions of human intestine ex vivo.

Li M, de Graaf IA, de Jager MH, Groothuis GM. Li M, et al. Biopharm Drug Dispos. 2017 Mar;38(2):127-138. doi: 10.1002/bdd.2047. Epub 2016 Nov 14. Biopharm Drug Dispos. 2017. PMID: 27757966

8

The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo.

Li M, de Graaf IA, van de Steeg E, de Jager MH, Groothuis GM. Li M, et al. Toxicol In Vitro. 2017 Apr;40:26-33. doi: 10.1016/j.tiv.2016.12.002. Epub 2016 Dec 7. Toxicol In Vitro. 2017. PMID: 27939799

9

On the toxicity and transport mechanisms of cisplatin in kidney tissues in comparison to a gold-based cytotoxic agent.

Spreckelmeyer S, Estrada-Ortiz N, Prins GGH, van der Zee M, Gammelgaard B, Stürup S, de Graaf IAM, Groothuis GMM, Casini A. Spreckelmeyer S, et al. Among authors: groothuis gmm. Metallomics. 2017 Dec 1;9(12):1786-1795. doi: 10.1039/c7mt00271h. Epub 2017 Nov 6. Metallomics. 2017. PMID: 29104982

10

Ex vivo toxicological evaluation of experimental anticancer gold(i) complexes with lansoprazole-type ligands.

Estrada-Ortiz N, Lopez-Gonzales E, Woods B, Stürup S, de Graaf IAM, Groothuis GMM, Casini A. Estrada-Ortiz N, et al. Among authors: groothuis gmm. Toxicol Res (Camb). 2019 Sep 20;8(6):885-895. doi: 10.1039/c9tx00149b. eCollection 2019 Nov 1. Toxicol Res (Camb). 2019. PMID: 32190293 Free PMC article.

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