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Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy.
Fang X, Bogomolovas J, Wu T, Zhang W, Liu C, Veevers J, Stroud MJ, Zhang Z, Ma X, Mu Y, Lao DH, Dalton ND, Gu Y, Wang C, Wang M, Liang Y, Lange S, Ouyang K, Peterson KL, Evans SM, Chen J. Fang X, et al. Among authors: peterson kl. J Clin Invest. 2017 Aug 1;127(8):3189-3200. doi: 10.1172/JCI94310. Epub 2017 Jul 24. J Clin Invest. 2017. PMID: 28737513 Free PMC article.
Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function.
Shen T, Aneas I, Sakabe N, Dirschinger RJ, Wang G, Smemo S, Westlund JM, Cheng H, Dalton N, Gu Y, Boogerd CJ, Cai CL, Peterson K, Chen J, Nobrega MA, Evans SM. Shen T, et al. J Clin Invest. 2011 Dec;121(12):4640-54. doi: 10.1172/JCI59472. Epub 2011 Nov 14. J Clin Invest. 2011. PMID: 22080862 Free PMC article.
MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.
Zhang D, Contu R, Latronico MV, Zhang J, Rizzi R, Catalucci D, Miyamoto S, Huang K, Ceci M, Gu Y, Dalton ND, Peterson KL, Guan KL, Brown JH, Chen J, Sonenberg N, Condorelli G. Zhang D, et al. Among authors: peterson kl. J Clin Invest. 2010 Aug;120(8):2805-16. doi: 10.1172/JCI43008. Epub 2010 Jul 19. J Clin Invest. 2010. PMID: 20644257 Free PMC article.
An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice.
Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW 2nd, Brown JH, Peterson KL, Omens JH, McCulloch AD, Chen J. Sheikh F, et al. Among authors: peterson kl. J Clin Invest. 2008 Dec;118(12):3870-80. doi: 10.1172/JCI34472. Epub 2008 Nov 3. J Clin Invest. 2008. PMID: 19033658 Free PMC article.
Loss of enigma homolog protein results in dilated cardiomyopathy.
Cheng H, Kimura K, Peter AK, Cui L, Ouyang K, Shen T, Liu Y, Gu Y, Dalton ND, Evans SM, Knowlton KU, Peterson KL, Chen J. Cheng H, et al. Among authors: peterson kl. Circ Res. 2010 Aug 6;107(3):348-56. doi: 10.1161/CIRCRESAHA.110.218735. Epub 2010 Jun 10. Circ Res. 2010. PMID: 20538684 Free PMC article.
Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease.
Sheikh F, Ouyang K, Campbell SG, Lyon RC, Chuang J, Fitzsimons D, Tangney J, Hidalgo CG, Chung CS, Cheng H, Dalton ND, Gu Y, Kasahara H, Ghassemian M, Omens JH, Peterson KL, Granzier HL, Moss RL, McCulloch AD, Chen J. Sheikh F, et al. Among authors: peterson kl. J Clin Invest. 2012 Apr;122(4):1209-21. doi: 10.1172/JCI61134. Epub 2012 Mar 19. J Clin Invest. 2012. PMID: 22426213 Free PMC article.
279 results