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Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy.
Fang X, Bogomolovas J, Wu T, Zhang W, Liu C, Veevers J, Stroud MJ, Zhang Z, Ma X, Mu Y, Lao DH, Dalton ND, Gu Y, Wang C, Wang M, Liang Y, Lange S, Ouyang K, Peterson KL, Evans SM, Chen J. Fang X, et al. Among authors: liang y. J Clin Invest. 2017 Aug 1;127(8):3189-3200. doi: 10.1172/JCI94310. Epub 2017 Jul 24. J Clin Invest. 2017. PMID: 28737513 Free PMC article.
Desmosomal junctions are necessary for adult sinus node function.
Mezzano V, Liang Y, Wright AT, Lyon RC, Pfeiffer E, Song MY, Gu Y, Dalton ND, Scheinman M, Peterson KL, Evans SM, Fowler S, Cerrone M, McCulloch AD, Sheikh F. Mezzano V, et al. Among authors: liang y. Cardiovasc Res. 2016 Aug 1;111(3):274-86. doi: 10.1093/cvr/cvw083. Epub 2016 Apr 20. Cardiovasc Res. 2016. PMID: 27097650 Free PMC article.
Plakophilin 2 gene therapy prevents and rescues arrhythmogenic right ventricular cardiomyopathy in a mouse model harboring patient genetics.
Bradford WH, Zhang J, Gutierrez-Lara EJ, Liang Y, Do A, Wang TM, Nguyen L, Mataraarachchi N, Wang J, Gu Y, McCulloch A, Peterson KL, Sheikh F. Bradford WH, et al. Among authors: liang y. Nat Cardiovasc Res. 2023 Dec;2(12):1246-1261. doi: 10.1038/s44161-023-00370-3. Epub 2023 Dec 7. Nat Cardiovasc Res. 2023. PMID: 39196150 Free PMC article.
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