Grantcharova V - Search Results

1

Systems biology driving drug development: from design to the clinical testing of the anti-ErbB3 antibody seribantumab (MM-121).

Schoeberl B, Kudla A, Masson K, Kalra A, Curley M, Finn G, Pace E, Harms B, Kim J, Kearns J, Fulgham A, Burenkova O, Grantcharova V, Yarar D, Paragas V, Fitzgerald J, Wainszelbaum M, West K, Mathews S, Nering R, Adiwijaya B, Garcia G, Kubasek B, Moyo V, Czibere A, Nielsen UB, MacBeath G. Schoeberl B, et al. Among authors: grantcharova v. NPJ Syst Biol Appl. 2017 Jan 5;3:16034. doi: 10.1038/npjsba.2016.34. eCollection 2017. NPJ Syst Biol Appl. 2017. PMID: 28725482 Free PMC article. Review.

2

Therapeutically targeting ErbB3: a key node in ligand-induced activation of the ErbB receptor-PI3K axis.

Schoeberl B, Pace EA, Fitzgerald JB, Harms BD, Xu L, Nie L, Linggi B, Kalra A, Paragas V, Bukhalid R, Grantcharova V, Kohli N, West KA, Leszczyniecka M, Feldhaus MJ, Kudla AJ, Nielsen UB. Schoeberl B, et al. Among authors: grantcharova v. Sci Signal. 2009 Jun 30;2(77):ra31. doi: 10.1126/scisignal.2000352. Sci Signal. 2009. PMID: 19567914

3

A systematic family-wide investigation reveals that ~30% of mammalian PDZ domains engage in PDZ-PDZ interactions.

Chang BH, Gujral TS, Karp ES, BuKhalid R, Grantcharova VP, MacBeath G. Chang BH, et al. Among authors: grantcharova vp. Chem Biol. 2011 Sep 23;18(9):1143-52. doi: 10.1016/j.chembiol.2011.06.013. Chem Biol. 2011. PMID: 21944753 Free PMC article.

4

Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays.

Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G. Stiffler MA, et al. Among authors: grantcharova vp. J Am Chem Soc. 2006 May 3;128(17):5913-22. doi: 10.1021/ja060943h. J Am Chem Soc. 2006. PMID: 16637659 Free PMC article.

5

PDZ domain binding selectivity is optimized across the mouse proteome.

Stiffler MA, Chen JR, Grantcharova VP, Lei Y, Fuchs D, Allen JE, Zaslavskaia LA, MacBeath G. Stiffler MA, et al. Among authors: grantcharova vp. Science. 2007 Jul 20;317(5836):364-9. doi: 10.1126/science.1144592. Science. 2007. PMID: 17641200 Free PMC article.

6

Effects of HER2 overexpression on cell signaling networks governing proliferation and migration.

Wolf-Yadlin A, Kumar N, Zhang Y, Hautaniemi S, Zaman M, Kim HD, Grantcharova V, Lauffenburger DA, White FM. Wolf-Yadlin A, et al. Among authors: grantcharova v. Mol Syst Biol. 2006;2:54. doi: 10.1038/msb4100094. Epub 2006 Oct 3. Mol Syst Biol. 2006. PMID: 17016520 Free PMC article.

7

Modifying the helical structure of DNA by design: recruitment of an architecture-specific protein to an enforced DNA bend.

Wolfe SA, Ferentz AE, Grantcharova V, Churchill ME, Verdine GL. Wolfe SA, et al. Among authors: grantcharova v. Chem Biol. 1995 Apr;2(4):213-21. doi: 10.1016/1074-5521(95)90271-6. Chem Biol. 1995. PMID: 9383423

8

Mechanisms of protein folding.

Grantcharova V, Alm EJ, Baker D, Horwich AL. Grantcharova V, et al. Curr Opin Struct Biol. 2001 Feb;11(1):70-82. doi: 10.1016/s0959-440x(00)00176-7. Curr Opin Struct Biol. 2001. PMID: 11179895 Review.

9

Simplified proteins: minimalist solutions to the 'protein folding problem'.

Plaxco KW, Riddle DS, Grantcharova V, Baker D. Plaxco KW, et al. Among authors: grantcharova v. Curr Opin Struct Biol. 1998 Feb;8(1):80-5. doi: 10.1016/s0959-440x(98)80013-4. Curr Opin Struct Biol. 1998. PMID: 9519299 Review.

10

Experiment and theory highlight role of native state topology in SH3 folding.

Riddle DS, Grantcharova VP, Santiago JV, Alm E, Ruczinski I, Baker D. Riddle DS, et al. Among authors: grantcharova vp. Nat Struct Biol. 1999 Nov;6(11):1016-24. doi: 10.1038/14901. Nat Struct Biol. 1999. PMID: 10542092

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