Kemp BE - Search Results

1

Metabolism: Energy sensing through a sugar diphosphate.

Kemp BE, Oakhill JS. Kemp BE, et al. Nature. 2017 Aug 3;548(7665):36-37. doi: 10.1038/nature23099. Epub 2017 Jul 19. Nature. 2017. PMID: 28723890 No abstract available.

2

Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding.

Langendorf CG, Ngoei KRW, Scott JW, Ling NXY, Issa SMA, Gorman MA, Parker MW, Sakamoto K, Oakhill JS, Kemp BE. Langendorf CG, et al. Among authors: kemp be. Nat Commun. 2016 Mar 8;7:10912. doi: 10.1038/ncomms10912. Nat Commun. 2016. PMID: 26952388 Free PMC article.

3

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms.

Pinkosky SL, Scott JW, Desjardins EM, Smith BK, Day EA, Ford RJ, Langendorf CG, Ling NXY, Nero TL, Loh K, Galic S, Hoque A, Smiles WJ, Ngoei KRW, Parker MW, Yan Y, Melcher K, Kemp BE, Oakhill JS, Steinberg GR. Pinkosky SL, et al. Among authors: kemp be. Nat Metab. 2020 Sep;2(9):873-881. doi: 10.1038/s42255-020-0245-2. Epub 2020 Jul 27. Nat Metab. 2020. PMID: 32719536 Free PMC article.

4

Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.

Scott JW, van Denderen BJ, Jorgensen SB, Honeyman JE, Steinberg GR, Oakhill JS, Iseli TJ, Koay A, Gooley PR, Stapleton D, Kemp BE. Scott JW, et al. Among authors: kemp be. Chem Biol. 2008 Nov 24;15(11):1220-30. doi: 10.1016/j.chembiol.2008.10.005. Chem Biol. 2008. PMID: 19022182

5

β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK).

Oakhill JS, Chen ZP, Scott JW, Steel R, Castelli LA, Ling N, Macaulay SL, Kemp BE. Oakhill JS, et al. Among authors: kemp be. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19237-41. doi: 10.1073/pnas.1009705107. Epub 2010 Oct 25. Proc Natl Acad Sci U S A. 2010. PMID: 20974912 Free PMC article.

6

AMPK functions as an adenylate charge-regulated protein kinase.

Oakhill JS, Scott JW, Kemp BE. Oakhill JS, et al. Among authors: kemp be. Trends Endocrinol Metab. 2012 Mar;23(3):125-32. doi: 10.1016/j.tem.2011.12.006. Epub 2012 Jan 26. Trends Endocrinol Metab. 2012. PMID: 22284532 Review.

7

β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase.

Ali N, Ling N, Krishnamurthy S, Oakhill JS, Scott JW, Stapleton DI, Kemp BE, Anand GS, Gooley PR. Ali N, et al. Among authors: kemp be. Sci Rep. 2016 Dec 21;6:39417. doi: 10.1038/srep39417. Sci Rep. 2016. PMID: 28000716 Free PMC article.

8

Impact of Genetic Variation on Human CaMKK2 Regulation by Ca²⁺-Calmodulin and Multisite Phosphorylation.

O'Brien MT, Oakhill JS, Ling NX, Langendorf CG, Hoque A, Dite TA, Means AR, Kemp BE, Scott JW. O'Brien MT, et al. Among authors: kemp be. Sci Rep. 2017 Feb 23;7:43264. doi: 10.1038/srep43264. Sci Rep. 2017. PMID: 28230171 Free PMC article.

9

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs.

Dite TA, Ling NXY, Scott JW, Hoque A, Galic S, Parker BL, Ngoei KRW, Langendorf CG, O'Brien MT, Kundu M, Viollet B, Steinberg GR, Sakamoto K, Kemp BE, Oakhill JS. Dite TA, et al. Among authors: kemp be. Nat Commun. 2017 Sep 18;8(1):571. doi: 10.1038/s41467-017-00628-y. Nat Commun. 2017. PMID: 28924239 Free PMC article.

10

Visualizing AMPK Drug Binding Sites Through Crystallization of Full-Length Phosphorylated α2β1γ1 Heterotrimer.

Langendorf CG, Oakhill JS, Kemp BE. Langendorf CG, et al. Among authors: kemp be. Methods Mol Biol. 2018;1732:15-27. doi: 10.1007/978-1-4939-7598-3_2. Methods Mol Biol. 2018. PMID: 29480466

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