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Chemically generated IgG2 bispecific antibodies through disulfide bridging.
Patterson JT, Gros E, Zhou H, Atassi G, Kerwin L, Carmody L, Zhu T, Jones B, Fu Y, Kaufmann GF. Patterson JT, et al. Among authors: zhu t. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3647-3652. doi: 10.1016/j.bmcl.2017.07.021. Epub 2017 Jul 8. Bioorg Med Chem Lett. 2017. PMID: 28720505
PSMA-targeted bispecific Fab conjugates that engage T cells.
Patterson JT, Isaacson J, Kerwin L, Atassi G, Duggal R, Bresson D, Zhu T, Zhou H, Fu Y, Kaufmann GF. Patterson JT, et al. Among authors: zhu t. Bioorg Med Chem Lett. 2017 Dec 15;27(24):5490-5495. doi: 10.1016/j.bmcl.2017.09.065. Epub 2017 Oct 6. Bioorg Med Chem Lett. 2017. PMID: 29126850
Discovery of novel cMET-targeting antibody Fab drug conjugates as potential treatment for solid tumors with highly expressed cMET.
Lim RK, Buschman M, Khasanov A, Ledesma A, Chen J, Nguyen T, Guo J, Li L, Huang J, Niu J, Kerwin L, Wang R, Guo Y, Zhu T, Kaufmann G, Zhang Y, Zhou H, Ji H, Fu Y. Lim RK, et al. Among authors: zhu t. Expert Opin Biol Ther. 2023 Jul-Dec;23(11):1137-1149. doi: 10.1080/14712598.2023.2292633. Epub 2023 Dec 15. Expert Opin Biol Ther. 2023. PMID: 38078403
8,359 results