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Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors.
Nguyen TX, Morrell A, Conda-Sheridan M, Marchand C, Agama K, Bermingham A, Bermingam A, Stephen AG, Chergui A, Naumova A, Fisher R, O'Keefe BR, Pommier Y, Cushman M. Nguyen TX, et al. Among authors: chergui a. J Med Chem. 2012 May 10;55(9):4457-78. doi: 10.1021/jm300335n. Epub 2012 Apr 26. J Med Chem. 2012. PMID: 22536944 Free PMC article.
Biochemical assays for the discovery of TDP1 inhibitors.
Marchand C, Huang SY, Dexheimer TS, Lea WA, Mott BT, Chergui A, Naumova A, Stephen AG, Rosenthal AS, Rai G, Murai J, Gao R, Maloney DJ, Jadhav A, Jorgensen WL, Simeonov A, Pommier Y. Marchand C, et al. Among authors: chergui a. Mol Cancer Ther. 2014 Aug;13(8):2116-26. doi: 10.1158/1535-7163.MCT-13-0952. Epub 2014 Jul 14. Mol Cancer Ther. 2014. PMID: 25024006 Free PMC article.
Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1).
Conda-Sheridan M, Reddy PV, Morrell A, Cobb BT, Marchand C, Agama K, Chergui A, Renaud A, Stephen AG, Bindu LK, Pommier Y, Cushman M. Conda-Sheridan M, et al. Among authors: chergui a. J Med Chem. 2013 Jan 10;56(1):182-200. doi: 10.1021/jm3014458. Epub 2012 Dec 21. J Med Chem. 2013. PMID: 23259865 Free PMC article.
5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.
Sirivolu VR, Vernekar SK, Marchand C, Naumova A, Chergui A, Renaud A, Stephen AG, Chen F, Sham YY, Pommier Y, Wang Z. Sirivolu VR, et al. Among authors: chergui a. J Med Chem. 2012 Oct 25;55(20):8671-84. doi: 10.1021/jm3008773. Epub 2012 Oct 8. J Med Chem. 2012. PMID: 23006064 Free PMC article.
Correction to Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)-Topoisomerase I (Top1) Inhibitors.
Nguyen TX, Morrell A, Conda-Sheridan M, Marchand C, Agama K, Bermingham A, Stephen AG, Chergui A, Naumova A, Fisher R, O'Keefe BR, Pommier Y, Cushman M. Nguyen TX, et al. Among authors: chergui a. J Med Chem. 2012 Aug 23;55(16):7297. doi: 10.1021/jm301167v. Epub 2012 Aug 14. J Med Chem. 2012. PMID: 22891611 Free PMC article. No abstract available.
Synthesis and biological evaluation of new carbohydrate-substituted indenoisoquinoline topoisomerase I inhibitors and improved syntheses of the experimental anticancer agents indotecan (LMP400) and indimitecan (LMP776).
Beck DE, Agama K, Marchand C, Chergui A, Pommier Y, Cushman M. Beck DE, et al. Among authors: chergui a. J Med Chem. 2014 Feb 27;57(4):1495-512. doi: 10.1021/jm401814y. Epub 2014 Feb 11. J Med Chem. 2014. PMID: 24517248 Free PMC article.
Discovery and structure-activity relationship of novel 2,3-dihydrobenzofuran-7-carboxamide and 2,3-dihydrobenzofuran-3(2H)-one-7-carboxamide derivatives as poly(ADP-ribose)polymerase-1 inhibitors.
Patel MR, Bhatt A, Steffen JD, Chergui A, Murai J, Pommier Y, Pascal JM, Trombetta LD, Fronczek FR, Talele TT. Patel MR, et al. Among authors: chergui a. J Med Chem. 2014 Jul 10;57(13):5579-601. doi: 10.1021/jm5002502. Epub 2014 Jun 25. J Med Chem. 2014. PMID: 24922587 Free PMC article.
28 results