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Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI-3231, a Well-Characterized Chemical Probe Available for Open Science.
J Med Chem. 2023 Feb 23;66(4):2832-2850. doi: 10.1021/acs.jmedchem.2c01884. Epub 2023 Feb 2.
J Med Chem. 2023.
PMID: 36727857
Free PMC article.
Concentration Dependence of the Unbound Partition Coefficient Kpuu and Its Application to Correct for Exposure-Related Discrepancies between Biochemical and Cellular Potency of KAT6A Inhibitors.
Trünkle C, Lechner C, Korr D, Bouché L, Barak N, Fernández-Montalván A, Süssmuth RD, Reichel A.
Trünkle C, et al.
Drug Metab Dispos. 2020 Jul;48(7):553-562. doi: 10.1124/dmd.120.090563. Epub 2020 May 1.
Drug Metab Dispos. 2020.
PMID: 32357973
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Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model.
Hoelzl MA, Heby-Henricson K, Gerling M, Dias JM, Kuiper RV, Trünkle C, Bergström Å, Ericson J, Toftgård R, Teglund S.
Hoelzl MA, et al. Among authors: trunkle c.
Dev Biol. 2017 Sep 1;429(1):132-146. doi: 10.1016/j.ydbio.2017.06.037. Epub 2017 Jul 5.
Dev Biol. 2017.
PMID: 28688895
Free PMC article.
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