Hirabayashi H - Search Results

1

Potent antiobesity effect of a short-length peptide YY-analogue continuously administered in mice.

Nishizawa N, Niida A, Adachi Y, Masuda Y, Kumano S, Yokoyama K, Asakawa T, Hirabayashi H, Amano N, Takekawa S, Ohtaki T, Asami T. Nishizawa N, et al. Among authors: hirabayashi h. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3829-3832. doi: 10.1016/j.bmcl.2017.06.055. Epub 2017 Jun 23. Bioorg Med Chem Lett. 2017. PMID: 28684122

2

Quantitative investigation of the impact of P-glycoprotein inhibition on drug transport across blood-brain barrier in rats.

Sugimoto H, Hirabayashi H, Kimura Y, Furuta A, Amano N, Moriwaki T. Sugimoto H, et al. Among authors: hirabayashi h. Drug Metab Dispos. 2011 Jan;39(1):8-14. doi: 10.1124/dmd.110.035774. Epub 2010 Oct 20. Drug Metab Dispos. 2011. PMID: 20962062

3

Establishment of in vitro P-glycoprotein inhibition assay and its exclusion criteria to assess the risk of drug-drug interaction at the drug discovery stage.

Sugimoto H, Matsumoto S, Tachibana M, Niwa S, Hirabayashi H, Amano N, Moriwaki T. Sugimoto H, et al. Among authors: hirabayashi h. J Pharm Sci. 2011 Sep;100(9):4013-23. doi: 10.1002/jps.22652. Epub 2011 Jun 15. J Pharm Sci. 2011. PMID: 21678427

4

Development of a quantification method for digoxin, a typical P-glycoprotein probe in clinical and non-clinical studies, using high performance liquid chromatography-tandem mass spectrometry: the usefulness of negative ionization mode to avoid competitive adduct-ion formation.

Hirabayashi H, Sugimoto H, Matsumoto S, Amano N, Moriwaki T. Hirabayashi H, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Dec 15;879(32):3837-44. doi: 10.1016/j.jchromb.2011.10.031. Epub 2011 Oct 29. J Chromatogr B Analyt Technol Biomed Life Sci. 2011. PMID: 22098716

5

Retrospective analysis of P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier in humans.

Sugimoto H, Hirabayashi H, Amano N, Moriwaki T. Sugimoto H, et al. Among authors: hirabayashi h. Drug Metab Dispos. 2013 Apr;41(4):683-8. doi: 10.1124/dmd.112.049577. Epub 2013 Jan 22. Drug Metab Dispos. 2013. PMID: 23340958

6

Melanin-Concentrating Hormone Receptor 1 Antagonists Lacking an Aliphatic Amine: Synthesis and Structure-Activity Relationships of Novel 1-(Imidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one Derivatives.

Igawa H, Takahashi M, Kakegawa K, Kina A, Ikoma M, Aida J, Yasuma T, Kawata Y, Ashina S, Yamamoto S, Kundu M, Khamrai U, Hirabayashi H, Nakayama M, Nagisa Y, Kasai S, Maekawa T. Igawa H, et al. Among authors: hirabayashi h. J Med Chem. 2016 Feb 11;59(3):1116-39. doi: 10.1021/acs.jmedchem.5b01704. Epub 2016 Jan 22. J Med Chem. 2016. PMID: 26736071

7

Unbound liver concentration is the true inhibitor concentration that determines cytochrome P450-mediated drug-drug interactions in rat liver.

Iwasaki S, Hirabayashi H, Funami M, Amano N. Iwasaki S, et al. Among authors: hirabayashi h. Xenobiotica. 2017 Jun;47(6):488-497. doi: 10.1080/00498254.2016.1204485. Epub 2016 Jul 20. Xenobiotica. 2017. PMID: 27435455

8

Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver.

Miyamoto M, Iwasaki S, Chisaki I, Nakagawa S, Amano N, Hirabayashi H. Miyamoto M, et al. Among authors: hirabayashi h. Xenobiotica. 2017 Dec;47(12):1052-1063. doi: 10.1080/00498254.2016.1265160. Epub 2017 Mar 2. Xenobiotica. 2017. PMID: 27892765

9

Antiobesity Effect of a Short-Length Peptide YY Analogue after Continuous Administration in Mice.

Nishizawa N, Niida A, Masuda Y, Kumano S, Yokoyama K, Hirabayashi H, Amano N, Ohtaki T, Asami T. Nishizawa N, et al. Among authors: hirabayashi h. ACS Med Chem Lett. 2017 May 1;8(6):628-631. doi: 10.1021/acsmedchemlett.7b00047. eCollection 2017 Jun 8. ACS Med Chem Lett. 2017. PMID: 28626523 Free PMC article.

10

Potent Body Weight-Lowering Effect of a Neuromedin U Receptor 2-selective PEGylated Peptide.

Kanematsu-Yamaki Y, Nishizawa N, Kaisho T, Nagai H, Mochida T, Asakawa T, Inooka H, Dote K, Fujita H, Matsumiya K, Hirabayashi H, Sakamoto J, Ohtaki T, Takekawa S, Asami T. Kanematsu-Yamaki Y, et al. Among authors: hirabayashi h. J Med Chem. 2017 Jul 27;60(14):6089-6097. doi: 10.1021/acs.jmedchem.7b00330. Epub 2017 Jul 18. J Med Chem. 2017. PMID: 28657315

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