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Page 1
Covalent inhibitors design and discovery.
De Cesco S, Kurian J, Dufresne C, Mittermaier AK, Moitessier N. De Cesco S, et al. Eur J Med Chem. 2017 Sep 29;138:96-114. doi: 10.1016/j.ejmech.2017.06.019. Epub 2017 Jun 10. Eur J Med Chem. 2017. PMID: 28651155 Review.
3-Oxo-hexahydro-1H-isoindole-4-carboxylic Acid as a Drug Chiral Bicyclic Scaffold: Structure-Based Design and Preparation of Conformationally Constrained Covalent and Noncovalent Prolyl Oligopeptidase Inhibitors.
Mariaule G, De Cesco S, Airaghi F, Kurian J, Schiavini P, Rocheleau S, Huskić I, Auclair K, Mittermaier A, Moitessier N. Mariaule G, et al. Among authors: de cesco s. J Med Chem. 2016 May 12;59(9):4221-34. doi: 10.1021/acs.jmedchem.5b01296. Epub 2015 Dec 14. J Med Chem. 2016. PMID: 26619267
A genetics-led approach defines the drug target landscape of 30 immune-related traits.
Fang H; ULTRA-DD Consortium; De Wolf H, Knezevic B, Burnham KL, Osgood J, Sanniti A, Lledó Lara A, Kasela S, De Cesco S, Wegner JK, Handunnetthi L, McCann FE, Chen L, Sekine T, Brennan PE, Marsden BD, Damerell D, O'Callaghan CA, Bountra C, Bowness P, Sundström Y, Milani L, Berg L, Göhlmann HW, Peeters PJ, Fairfax BP, Sundström M, Knight JC. Fang H, et al. Among authors: de cesco s. Nat Genet. 2019 Jul;51(7):1082-1091. doi: 10.1038/s41588-019-0456-1. Epub 2019 Jun 28. Nat Genet. 2019. PMID: 31253980 Free PMC article.
13 results