Randazzo A - Search Results

1

Decoration of Chondroitin Polysaccharide with Threonine: Synthesis, Conformational Study, and Ice-Recrystallization Inhibition Activity.

Laezza A, Casillo A, Cosconati S, Biggs CI, Fabozzi A, Paduano L, Iadonisi A, Novellino E, Gibson MI, Randazzo A, Corsaro MM, Bedini E. Laezza A, et al. Among authors: randazzo a. Biomacromolecules. 2017 Aug 14;18(8):2267-2276. doi: 10.1021/acs.biomac.7b00326. Epub 2017 Jul 11. Biomacromolecules. 2017. PMID: 28650649 Free PMC article.

2

Tandem application of virtual screening and NMR experiments in the discovery of brand new DNA quadruplex groove binders.

Cosconati S, Marinelli L, Trotta R, Virno A, Mayol L, Novellino E, Olson AJ, Randazzo A. Cosconati S, et al. Among authors: randazzo a. J Am Chem Soc. 2009 Nov 18;131(45):16336-7. doi: 10.1021/ja9063662. J Am Chem Soc. 2009. PMID: 19856964

3

Structural and conformational requisites in DNA quadruplex groove binding: another piece to the puzzle.

Cosconati S, Marinelli L, Trotta R, Virno A, De Tito S, Romagnoli R, Pagano B, Limongelli V, Giancola C, Baraldi PG, Mayol L, Novellino E, Randazzo A. Cosconati S, et al. Among authors: randazzo a. J Am Chem Soc. 2010 May 12;132(18):6425-33. doi: 10.1021/ja1003872. J Am Chem Soc. 2010. PMID: 20394365

4

The triazatruxene derivative azatrux binds to the parallel form of the human telomeric G-quadruplex under molecular crowding conditions: biophysical and molecular modeling studies.

Petraccone L, Fotticchia I, Cummaro A, Pagano B, Ginnari-Satriani L, Haider S, Randazzo A, Novellino E, Neidle S, Giancola C. Petraccone L, et al. Among authors: randazzo a. Biochimie. 2011 Aug;93(8):1318-27. doi: 10.1016/j.biochi.2011.05.017. Epub 2011 May 30. Biochimie. 2011. PMID: 21641960

5

A more detailed picture of the interactions between virtual screening-derived hits and the DNA G-quadruplex: NMR, molecular modelling and ITC studies.

Trotta R, De Tito S, Lauri I, La Pietra V, Marinelli L, Cosconati S, Martino L, Conte MR, Mayol L, Novellino E, Randazzo A. Trotta R, et al. Among authors: randazzo a. Biochimie. 2011 Aug;93(8):1280-7. doi: 10.1016/j.biochi.2011.05.021. Epub 2011 May 30. Biochimie. 2011. PMID: 21658428

6

State-of-the-art methodologies for the discovery and characterization of DNA G-quadruplex binders.

Pagano B, Cosconati S, Gabelica V, Petraccone L, De Tito S, Marinelli L, La Pietra V, di Leva FS, Lauri I, Trotta R, Novellino E, Giancola C, Randazzo A. Pagano B, et al. Among authors: randazzo a. Curr Pharm Des. 2012;18(14):1880-99. doi: 10.2174/138161212799958332. Curr Pharm Des. 2012. PMID: 22376104 Free article. Review.

7

High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity.

Russo Krauss I, Merlino A, Randazzo A, Novellino E, Mazzarella L, Sica F. Russo Krauss I, et al. Among authors: randazzo a. Nucleic Acids Res. 2012 Sep;40(16):8119-28. doi: 10.1093/nar/gks512. Epub 2012 Jun 4. Nucleic Acids Res. 2012. PMID: 22669903 Free PMC article.

8

Shooting for selective druglike G-quadruplex binders: evidence for telomeric DNA damage and tumor cell death.

Cosconati S, Rizzo A, Trotta R, Pagano B, Iachettini S, De Tito S, Lauri I, Fotticchia I, Giustiniano M, Marinelli L, Giancola C, Novellino E, Biroccio A, Randazzo A. Cosconati S, et al. Among authors: randazzo a. J Med Chem. 2012 Nov 26;55(22):9785-92. doi: 10.1021/jm301019w. Epub 2012 Oct 18. J Med Chem. 2012. PMID: 23057850

9

The G-triplex DNA.

Limongelli V, De Tito S, Cerofolini L, Fragai M, Pagano B, Trotta R, Cosconati S, Marinelli L, Novellino E, Bertini I, Randazzo A, Luchinat C, Parrinello M. Limongelli V, et al. Among authors: randazzo a. Angew Chem Int Ed Engl. 2013 Feb 18;52(8):2269-73. doi: 10.1002/anie.201206522. Epub 2013 Jan 17. Angew Chem Int Ed Engl. 2013. PMID: 23335456 No abstract available.

10

Differential scanning calorimetry to investigate G-quadruplexes structural stability.

Pagano B, Randazzo A, Fotticchia I, Novellino E, Petraccone L, Giancola C. Pagano B, et al. Among authors: randazzo a. Methods. 2013 Nov;64(1):43-51. doi: 10.1016/j.ymeth.2013.02.018. Epub 2013 Mar 14. Methods. 2013. PMID: 23500655

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