Leach MO - Search Results

1

Pediatric and adult glioblastoma radiosensitization induced by PI3K/mTOR inhibition causes early metabolic alterations detected by nuclear magnetic resonance spectroscopy.

Agliano A, Balarajah G, Ciobota DM, Sidhu J, Clarke PA, Jones C, Workman P, Leach MO, Al-Saffar NMS. Agliano A, et al. Among authors: leach mo. Oncotarget. 2017 Jul 18;8(29):47969-47983. doi: 10.18632/oncotarget.18206. Oncotarget. 2017. PMID: 28624789 Free PMC article.

2

Magnetic resonance spectroscopic pharmacodynamic markers of the heat shock protein 90 inhibitor 17-allylamino,17-demethoxygeldanamycin (17AAG) in human colon cancer models.

Chung YL, Troy H, Banerji U, Jackson LE, Walton MI, Stubbs M, Griffiths JR, Judson IR, Leach MO, Workman P, Ronen SM. Chung YL, et al. Among authors: leach mo. J Natl Cancer Inst. 2003 Nov 5;95(21):1624-33. doi: 10.1093/jnci/djg084. J Natl Cancer Inst. 2003. PMID: 14600095

3

A phase I study of SR-4554 via intravenous administration for noninvasive investigation of tumor hypoxia by magnetic resonance spectroscopy in patients with malignancy.

Seddon BM, Payne GS, Simmons L, Ruddle R, Grimshaw R, Tan S, Turner A, Raynaud F, Halbert G, Leach MO, Judson I, Workman P. Seddon BM, et al. Among authors: leach mo. Clin Cancer Res. 2003 Nov 1;9(14):5101-12. Clin Cancer Res. 2003. PMID: 14613987 Review.

4

Magnetic resonance spectroscopy monitoring of mitogen-activated protein kinase signaling inhibition.

Beloueche-Babari M, Jackson LE, Al-Saffar NM, Workman P, Leach MO, Ronen SM. Beloueche-Babari M, et al. Among authors: leach mo. Cancer Res. 2005 Apr 15;65(8):3356-63. doi: 10.1158/10.1158/0008-5472.CAN-03-2981. Cancer Res. 2005. PMID: 15833869

5

Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models.

Al-Saffar NM, Troy H, Ramírez de Molina A, Jackson LE, Madhu B, Griffiths JR, Leach MO, Workman P, Lacal JC, Judson IR, Chung YL. Al-Saffar NM, et al. Among authors: leach mo. Cancer Res. 2006 Jan 1;66(1):427-34. doi: 10.1158/0008-5472.CAN-05-1338. Cancer Res. 2006. PMID: 16397258

6

Identification of magnetic resonance detectable metabolic changes associated with inhibition of phosphoinositide 3-kinase signaling in human breast cancer cells.

Beloueche-Babari M, Jackson LE, Al-Saffar NM, Eccles SA, Raynaud FI, Workman P, Leach MO, Ronen SM. Beloueche-Babari M, et al. Among authors: leach mo. Mol Cancer Ther. 2006 Jan;5(1):187-96. doi: 10.1158/1535-7163.MCT-03-0220. Mol Cancer Ther. 2006. PMID: 16432178

7

Minimally invasive pharmacokinetic and pharmacodynamic technologies in hypothesis-testing clinical trials of innovative therapies.

Workman P, Aboagye EO, Chung YL, Griffiths JR, Hart R, Leach MO, Maxwell RJ, McSheehy PM, Price PM, Zweit J; Cancer Research UK Pharmacodynamic/Pharmacokinetic Technologies Advisory Committee. Workman P, et al. Among authors: leach mo. J Natl Cancer Inst. 2006 May 3;98(9):580-98. doi: 10.1093/jnci/djj162. J Natl Cancer Inst. 2006. PMID: 16670384 Review.

8

Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of a novel histone deacetylase inhibitor, LAQ824, in human colon carcinoma cells and xenografts.

Chung YL, Troy H, Kristeleit R, Aherne W, Jackson LE, Atadja P, Griffiths JR, Judson IR, Workman P, Leach MO, Beloueche-Babari M. Chung YL, et al. Among authors: leach mo. Neoplasia. 2008 Apr;10(4):303-13. doi: 10.1593/neo.07834. Neoplasia. 2008. PMID: 18392140 Free PMC article.

9

The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy.

Al-Saffar NM, Jackson LE, Raynaud FI, Clarke PA, Ramírez de Molina A, Lacal JC, Workman P, Leach MO. Al-Saffar NM, et al. Among authors: leach mo. Cancer Res. 2010 Jul 1;70(13):5507-17. doi: 10.1158/0008-5472.CAN-09-4476. Epub 2010 Jun 15. Cancer Res. 2010. PMID: 20551061 Free PMC article.

10

Modulation of melanoma cell phospholipid metabolism in response to heat shock protein 90 inhibition.

Beloueche-Babari M, Arunan V, Jackson LE, Perusinghe N, Sharp SY, Workman P, Leach MO. Beloueche-Babari M, et al. Among authors: leach mo. Oncotarget. 2010 Jul;1(3):185-97. doi: 10.18632/oncotarget.125. Oncotarget. 2010. PMID: 21037799 Free PMC article.

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