Chatham L - Search Results

1

A functional SUMO-motif in the active site of PIM1 promotes its degradation via RNF4, and stimulates protein kinase activity.

Iyer RS, Chatham L, Sleigh R, Meek DW. Iyer RS, et al. Among authors: chatham l. Sci Rep. 2017 Jun 15;7(1):3598. doi: 10.1038/s41598-017-03775-w. Sci Rep. 2017. PMID: 28620180 Free PMC article.

2

Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes.

Haines C, Elcombe BM, Chatham LR, Vardy A, Higgins LG, Elcombe CR, Lake BG. Haines C, et al. Toxicology. 2018 Mar 1;396-397:23-32. doi: 10.1016/j.tox.2018.02.001. Epub 2018 Feb 6. Toxicology. 2018. PMID: 29425889

3

Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats.

Haines C, Chatham LR, Vardy A, Elcombe CR, Foster JR, Lake BG. Haines C, et al. Toxicology. 2018 May 1;400-401:20-27. doi: 10.1016/j.tox.2018.03.002. Epub 2018 Mar 13. Toxicology. 2018. PMID: 29548889

4

Evidence that the capacity of nongenotoxic carcinogens to induce oxidative stress is subject to marked variability.

Henderson CJ, Cameron AR, Chatham L, Stanley LA, Wolf CR. Henderson CJ, et al. Among authors: chatham l. Toxicol Sci. 2015 May;145(1):138-48. doi: 10.1093/toxsci/kfv039. Epub 2015 Feb 17. Toxicol Sci. 2015. PMID: 25690736 Free PMC article.

5

Comparative studies on the effects of sodium phenobarbital and two other constitutive androstane receptor (CAR) activators on induction of cytochrome P450 enzymes and replicative DNA synthesis in cultured hepatocytes from wild type and CAR knockout rats.

Goettel M, Fegert I, Honarvar N, Vardy A, Haines C, Chatham LR, Lake BG. Goettel M, et al. Among authors: chatham lr. Toxicology. 2020 Mar 30;433-434:152394. doi: 10.1016/j.tox.2020.152394. Epub 2020 Feb 3. Toxicology. 2020. PMID: 32027962

6

Comparison of the hepatic and thyroid gland effects of sodium phenobarbital and pregnenolone-16α-carbonitrile in wild-type and constitutive androstane receptor (CAR)/pregnane X receptor (PXR) knockout rats.

Haines C, Chatham LR, Vardy A, Elcombe CR, Foster JR, Lake BG. Haines C, et al. Xenobiotica. 2019 Feb;49(2):227-238. doi: 10.1080/00498254.2018.1437300. Epub 2018 Mar 26. Xenobiotica. 2019. PMID: 29424600

7

An assay for screening xenobiotics for inhibition of rat thyroid gland peroxidase activity.

Price RJ, Burch R, Chatham LR, Higgins LG, Currie RA, Lake BG. Price RJ, et al. Xenobiotica. 2020 Mar;50(3):318-322. doi: 10.1080/00498254.2019.1629044. Epub 2019 Jun 19. Xenobiotica. 2020. PMID: 31180273

8

Metazachlor: Mode of action analysis for rat liver tumour formation and human relevance.

Wiemann C, Goettel M, Vardy A, Elcombe BM, Elcombe CR, Chatham LR, Wang H, Li L, Buesen R, Honarvar N, Treumann S, Marxfeld H, Groeters S, Lake BG. Wiemann C, et al. Among authors: chatham lr. Toxicology. 2019 Oct 1;426:152282. doi: 10.1016/j.tox.2019.152282. Epub 2019 Aug 26. Toxicology. 2019. PMID: 31465819

9

Piperonyl butoxide: Mode of action analysis for mouse liver tumour formation and human relevance.

Lake BG, Price RJ, Scott MP, Chatham LR, Vardy A, Osimitz TG. Lake BG, et al. Among authors: chatham lr. Toxicology. 2020 Jun;439:152465. doi: 10.1016/j.tox.2020.152465. Epub 2020 Apr 19. Toxicology. 2020. PMID: 32320717

10

Differential lymphatic versus portal vein uptake of the synthetic pyrethroids deltamethrin and cis-permethrin in rats.

Higgins LG, Chatham LR, Tomczynski SL, MacLeod AK, Moreau M, Clewell HJ, Yoon M, Creek MR, Osimitz TG, Lake BG. Higgins LG, et al. Among authors: chatham lr. Toxicology. 2020 Oct;443:152563. doi: 10.1016/j.tox.2020.152563. Epub 2020 Aug 14. Toxicology. 2020. PMID: 32805335

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