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PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth.
Kuchay S, Giorgi C, Simoneschi D, Pagan J, Missiroli S, Saraf A, Florens L, Washburn MP, Collazo-Lorduy A, Castillo-Martin M, Cordon-Cardo C, Sebti SM, Pinton P, Pagano M. Kuchay S, et al. Among authors: pagan j. Nature. 2017 Jun 22;546(7659):554-558. doi: 10.1038/nature22965. Epub 2017 Jun 14. Nature. 2017. PMID: 28614300 Free PMC article.
SnapShot: F box proteins I.
Skaar JR, Pagan JK, Pagano M. Skaar JR, et al. Cell. 2009 Jun 12;137(6):1160-1160.e1. doi: 10.1016/j.cell.2009.05.039. Cell. 2009. PMID: 19524517 Free article. No abstract available.
SnapShot: F Box Proteins II.
Skaar JR, D'Angiolella V, Pagan JK, Pagano M. Skaar JR, et al. Cell. 2009 Jun 26;137(7):1358, 1358.e1. doi: 10.1016/j.cell.2009.05.040. Cell. 2009. PMID: 19563764 Free article. No abstract available.
FBXW5 controls centrosome number.
Pagan J, Pagano M. Pagan J, et al. Nat Cell Biol. 2011 Aug 1;13(8):888-90. doi: 10.1038/ncb2312. Nat Cell Biol. 2011. PMID: 21808243 Free PMC article.
SCF ubiquitin ligase-targeted therapies.
Skaar JR, Pagan JK, Pagano M. Skaar JR, et al. Nat Rev Drug Discov. 2014 Dec;13(12):889-903. doi: 10.1038/nrd4432. Epub 2014 Nov 14. Nat Rev Drug Discov. 2014. PMID: 25394868 Free PMC article. Review.
381 results