Wisialowski T - Search Results

1

Novel 3-fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.

Mitton-Fry MJ, Brickner SJ, Hamel JC, Barham R, Brennan L, Casavant JM, Ding X, Finegan S, Hardink J, Hoang T, Huband MD, Maloney M, Marfat A, McCurdy SP, McLeod D, Subramanyam C, Plotkin M, Reilly U, Schafer J, Stone GG, Uccello DP, Wisialowski T, Yoon K, Zaniewski R, Zook C. Mitton-Fry MJ, et al. Among authors: wisialowski t. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3353-3358. doi: 10.1016/j.bmcl.2017.06.009. Epub 2017 Jun 3. Bioorg Med Chem Lett. 2017. PMID: 28610977

2

A HESI consortium approach to assess the human predictive value of non-clinical repolarization assays.

Trepakova ES, Koerner J, Pettit SD, Valentin JP; HESI Pro-Arrhythmia Committee. Trepakova ES, et al. J Pharmacol Toxicol Methods. 2009 Jul-Aug;60(1):45-50. doi: 10.1016/j.vascn.2009.05.002. Epub 2009 May 9. J Pharmacol Toxicol Methods. 2009. PMID: 19439186

3

Differentiation of arrhythmia risk of the antibacterials moxifloxacin, erythromycin, and telithromycin based on analysis of monophasic action potential duration alternans and cardiac instability.

Wisialowski T, Crimin K, Engtrakul J, O'Donnell J, Fermini B, Fossa AA. Wisialowski T, et al. J Pharmacol Exp Ther. 2006 Jul;318(1):352-9. doi: 10.1124/jpet.106.101881. Epub 2006 Apr 13. J Pharmacol Exp Ther. 2006. PMID: 16614168

4

L-type calcium channel antagonism - Translation from in vitro to in vivo.

Fermini B, Ramirez DS, Sun S, Bassyouni A, Hemkens M, Wisialowski T, Jenkinson S. Fermini B, et al. Among authors: wisialowski t. J Pharmacol Toxicol Methods. 2017 Mar-Apr;84:86-92. doi: 10.1016/j.vascn.2016.11.002. Epub 2016 Nov 15. J Pharmacol Toxicol Methods. 2017. PMID: 27856310

5

Electrical alternans and hemodynamics in the anesthetized guinea pig can discriminate the cardiac safety of antidepressants.

Fossa AA, Gorczyca W, Wisialowski T, Yasgar A, Wang E, Crimin K, Volberg W, Zhou J. Fossa AA, et al. Among authors: wisialowski t. J Pharmacol Toxicol Methods. 2007 Jan-Feb;55(1):78-85. doi: 10.1016/j.vascn.2006.03.007. Epub 2006 Apr 25. J Pharmacol Toxicol Methods. 2007. PMID: 16678449

6

Use of high throughput ion channel profiling and statistical modeling to predict off-target arrhythmia risk - One pharma's experience and perspective.

Watt ED, Lee T, Feng SL, Kilfoil P, Ackley D, Keefer C, Wisialowski T, Jenkinson S. Watt ED, et al. Among authors: wisialowski t. J Pharmacol Toxicol Methods. 2022 Nov-Dec;118:107213. doi: 10.1016/j.vascn.2022.107213. Epub 2022 Sep 7. J Pharmacol Toxicol Methods. 2022. PMID: 36084863

7

Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig.

Fossa AA, Wisialowski T, Wolfgang E, Wang E, Avery M, Raunig DL, Fermini B. Fossa AA, et al. Among authors: wisialowski t. Eur J Pharmacol. 2004 Feb 20;486(2):209-21. doi: 10.1016/j.ejphar.2003.12.028. Eur J Pharmacol. 2004. PMID: 14975710

8

Azithromycin/chloroquine combination does not increase cardiac instability despite an increase in monophasic action potential duration in the anesthetized guinea pig.

Fossa AA, Wisialowski T, Duncan JN, Deng S, Dunne M. Fossa AA, et al. Among authors: wisialowski t. Am J Trop Med Hyg. 2007 Nov;77(5):929-38. Am J Trop Med Hyg. 2007. PMID: 17984356

9

Statistical power analysis of cardiovascular safety pharmacology studies in conscious rats.

Bhatt S, Li D, Flynn D, Wisialowski T, Hemkens M, Steidl-Nichols J. Bhatt S, et al. Among authors: wisialowski t. J Pharmacol Toxicol Methods. 2016 Sep-Oct;81:128-35. doi: 10.1016/j.vascn.2016.04.003. Epub 2016 Apr 9. J Pharmacol Toxicol Methods. 2016. PMID: 27071954

10

Cardiac sodium channel antagonism - Translation of preclinical in vitro assays to clinical QRS prolongation.

Jenkinson S, Bassyouni A, Cordes J, Fermini B, Guo D, Potter DM, Ramirez DS, Steidl-Nichols J, Sun S, Wisialowski T. Jenkinson S, et al. Among authors: wisialowski t. J Pharmacol Toxicol Methods. 2018 Jan-Feb;89:9-18. doi: 10.1016/j.vascn.2017.10.002. Epub 2017 Oct 16. J Pharmacol Toxicol Methods. 2018. PMID: 29042254

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