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Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression.
Pirat C, Dacquet C, Leclerc V, Hennuyer N, Beucher-Gaudin M, Zanirato G, Géant A, Staels B, Ktorza A, Farce A, Caignard DH, Berthelot P, Lebegue N. Pirat C, et al. Among authors: staels b. Eur J Med Chem. 2017 Sep 8;137:310-326. doi: 10.1016/j.ejmech.2017.06.006. Epub 2017 Jun 12. Eur J Med Chem. 2017. PMID: 28609708
Studies towards the conception of new selective PPARbeta/delta ligands.
Basséne CE, Suzenet F, Hennuyer N, Staels B, Caignard DH, Dacquet C, Renard P, Guillaumet G. Basséne CE, et al. Among authors: staels b. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4528-32. doi: 10.1016/j.bmcl.2006.06.028. Epub 2006 Jun 23. Bioorg Med Chem Lett. 2006. PMID: 16797985
Novel 1,3-dicarbonyl compounds having 2(3H)-benzazolonic heterocycles as PPARgamma agonists.
Blanc-Delmas E, Lebegue N, Wallez V, Leclerc V, Yous S, Carato P, Farce A, Bennejean C, Renard P, Caignard DH, Audinot-Bouchez V, Chomarat P, Boutin J, Hennuyer N, Louche K, Carmona MC, Staels B, Pénicaud L, Casteilla L, Lonchampt M, Dacquet C, Chavatte P, Berthelot P, Lesieur D. Blanc-Delmas E, et al. Among authors: staels b. Bioorg Med Chem. 2006 Nov 15;14(22):7377-91. doi: 10.1016/j.bmc.2006.07.029. Epub 2006 Aug 2. Bioorg Med Chem. 2006. PMID: 16887353
Overview of nomenclature of nuclear receptors.
Germain P, Staels B, Dacquet C, Spedding M, Laudet V. Germain P, et al. Among authors: staels b. Pharmacol Rev. 2006 Dec;58(4):685-704. doi: 10.1124/pr.58.4.2. Pharmacol Rev. 2006. PMID: 17132848 Review.
S 26948: a new specific peroxisome proliferator activated receptor gamma modulator with potent antidiabetes and antiatherogenic effects.
Carmona MC, Louche K, Lefebvre B, Pilon A, Hennuyer N, Audinot-Bouchez V, Fievet C, Torpier G, Formstecher P, Renard P, Lefebvre P, Dacquet C, Staels B, Casteilla L, Pénicaud L; Consortium of the French Ministry of Research and Technology. Carmona MC, et al. Among authors: staels b. Diabetes. 2007 Nov;56(11):2797-808. doi: 10.2337/db06-1734. Epub 2007 Aug 17. Diabetes. 2007. PMID: 17704298
805 results