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Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis.
Worthmann A, John C, Rühlemann MC, Baguhl M, Heinsen FA, Schaltenberg N, Heine M, Schlein C, Evangelakos I, Mineo C, Fischer M, Dandri M, Kremoser C, Scheja L, Franke A, Shaul PW, Heeren J. Worthmann A, et al. Among authors: john c. Nat Med. 2017 Jul;23(7):839-849. doi: 10.1038/nm.4357. Epub 2017 Jun 12. Nat Med. 2017. PMID: 28604703
Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development.
Berbée JF, Boon MR, Khedoe PP, Bartelt A, Schlein C, Worthmann A, Kooijman S, Hoeke G, Mol IM, John C, Jung C, Vazirpanah N, Brouwers LP, Gordts PL, Esko JD, Hiemstra PS, Havekes LM, Scheja L, Heeren J, Rensen PC. Berbée JF, et al. Among authors: john c. Nat Commun. 2015 Mar 10;6:6356. doi: 10.1038/ncomms7356. Nat Commun. 2015. PMID: 25754609 Free PMC article.
Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport.
Bartelt A, John C, Schaltenberg N, Berbée JFP, Worthmann A, Cherradi ML, Schlein C, Piepenburg J, Boon MR, Rinninger F, Heine M, Toedter K, Niemeier A, Nilsson SK, Fischer M, Wijers SL, van Marken Lichtenbelt W, Scheja L, Rensen PCN, Heeren J. Bartelt A, et al. Among authors: john c. Nat Commun. 2017 Apr 19;8:15010. doi: 10.1038/ncomms15010. Nat Commun. 2017. PMID: 28422089 Free PMC article. Clinical Trial.
Cold-Induced Lipoprotein Clearance in Cyp7b1-Deficient Mice.
Evangelakos I, Kuhl A, Baguhl M, Schlein C, John C, Rohde JK, Heine M, Heeren J, Worthmann A. Evangelakos I, et al. Among authors: john c. Front Cell Dev Biol. 2022 Apr 11;10:836741. doi: 10.3389/fcell.2022.836741. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35478959 Free PMC article.
Liver infiltrating T cells regulate bile acid metabolism in experimental cholangitis.
Glaser F, John C, Engel B, Höh B, Weidemann S, Dieckhoff J, Stein S, Becker N, Casar C, Schuran FA, Wieschendorf B, Preti M, Jessen F, Franke A, Carambia A, Lohse AW, Ittrich H, Herkel J, Heeren J, Schramm C, Schwinge D. Glaser F, et al. Among authors: john c. J Hepatol. 2019 Oct;71(4):783-792. doi: 10.1016/j.jhep.2019.05.030. Epub 2019 Jun 14. J Hepatol. 2019. PMID: 31207266
1,039 results