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The deuterium isotope effect on the NMR signal of the low-barrier hydrogen bond in a transition-state analog complex of chymotrypsin.
Cassidy CS, Lin J, Frey PA. Cassidy CS, et al. Among authors: lin j. Biochem Biophys Res Commun. 2000 Jul 5;273(2):789-92. doi: 10.1006/bbrc.2000.2986. Biochem Biophys Res Commun. 2000. PMID: 10873682
The participation of a low-barrier hydrogen bond (LBHB) in the mechanism of action of chymotrypsin introduces a new role for Asp 102 and His 57 in catalysis [C. S. Cassidy, J. Lin, and P. A. Frey (1997) Biochemistry 36, 4576-4584]. It is postulated that the LBHB inc …
The participation of a low-barrier hydrogen bond (LBHB) in the mechanism of action of chymotrypsin introduces a new role for Asp 102 and His …
Correlations of the basicity of His 57 with transition state analogue binding, substrate reactivity, and the strength of the low-barrier hydrogen bond in chymotrypsin.
Lin J, Cassidy CS, Frey PA. Lin J, et al. Biochemistry. 1998 Aug 25;37(34):11940-8. doi: 10.1021/bi980278s. Biochemistry. 1998. PMID: 9718318
The apparent pKa of His 57-Nepsilon2 for the chymotrypsin-N-Ac-L-Leu-DL-Phe-CF3 complex is 10.6 at 25 degrees C, whereas it is 12.0 at 5 degrees C [Cassidy, C. S., Lin, J. L., and Frey, P. A. (1997) Biochemistry 36, 4576-4584]. The apparent discrepancy is likely to …
The apparent pKa of His 57-Nepsilon2 for the chymotrypsin-N-Ac-L-Leu-DL-Phe-CF3 complex is 10.6 at 25 degrees C, whereas it is 12.0 at 5 deg …
Fractionation factors and activation energies for exchange of the low barrier hydrogen bonding proton in peptidyl trifluoromethyl ketone complexes of chymotrypsin.
Lin J, Westler WM, Cleland WW, Markley JL, Frey PA. Lin J, et al. Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14664-8. doi: 10.1073/pnas.95.25.14664. Proc Natl Acad Sci U S A. 1998. PMID: 9843946 Free PMC article.
It was found that the previously noted correlations between the inhibition constants (Ki 170-1.2 microM) and the chemical shifts of His 57-Hdelta1 (delta2, 2-dimethylsilapentane-5-sulfonic acid 18.61-18.95) for this series of peptidyl trifluoromethyl ketones with chymotrypsin [ …
It was found that the previously noted correlations between the inhibition constants (Ki 170-1.2 microM) and the chemical shifts of His 57-H …
41,204 results
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