Hilden I - Search Results

1

Concizumab, an anti-tissue factor pathway inhibitor antibody, induces increased thrombin generation in plasma from haemophilia patients and healthy subjects measured by the thrombin generation assay.

Waters EK, Sigh J, Friedrich U, Hilden I, Sørensen BB. Waters EK, et al. Among authors: hilden i. Haemophilia. 2017 Sep;23(5):769-776. doi: 10.1111/hae.13260. Epub 2017 Jun 8. Haemophilia. 2017. PMID: 28594458

2

Functional characteristics of N8, a new recombinant FVIII.

Christiansen ML, Balling KW, Persson E, Hilden I, Bagger-Sørensen A, Sørensen BB, Viuff D, Segel S, Klausen NK, Ezban M, Lethagen S, Steenstrup TD, Kjalke M. Christiansen ML, et al. Among authors: hilden i. Haemophilia. 2010 Nov;16(6):878-87. doi: 10.1111/j.1365-2516.2010.02333.x. Haemophilia. 2010. PMID: 20546031

3

Thrombin generation assay using factor XIa to measure factors VIII and IX and their glycoPEGylated derivatives is robust and sensitive.

Waters EK, Hilden I, Sørensen BB, Ezban M, Holm PK. Waters EK, et al. Among authors: hilden i. J Thromb Haemost. 2015 Nov;13(11):2041-52. doi: 10.1111/jth.13134. Epub 2015 Oct 1. J Thromb Haemost. 2015. PMID: 26340413 Free article.

4

Measurement of plasma and platelet tissue factor pathway inhibitor, factor V and Protein S in people with haemophilia.

Ellery PER, Hilden I, Thyregod P, Martinez ND, Maroney SA, Gill JC, Mast AE. Ellery PER, et al. Among authors: hilden i. Haemophilia. 2019 Nov;25(6):1083-1091. doi: 10.1111/hae.13860. Epub 2019 Oct 14. Haemophilia. 2019. PMID: 31608540 Free PMC article.

5

Target-mediated clearance and bio-distribution of a monoclonal antibody against the Kunitz-type protease inhibitor 2 domain of Tissue Factor Pathway Inhibitor.

Hansen L, Petersen LC, Lauritzen B, Clausen JT, Grell SN, Agersø H, Sørensen BB, Hilden I, Almholt K. Hansen L, et al. Among authors: hilden i. Thromb Res. 2014 Mar;133(3):464-71. doi: 10.1016/j.thromres.2013.12.015. Epub 2013 Dec 17. Thromb Res. 2014. PMID: 24393663

6

Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model.

Hilden I, Lauritzen B, Sørensen BB, Clausen JT, Jespersgaard C, Krogh BO, Bowler AN, Breinholt J, Gruhler A, Svensson LA, Petersen HH, Petersen LC, Balling KW, Hansen L, Hermit MB, Egebjerg T, Friederichsen B, Ezban M, Bjørn SE. Hilden I, et al. Blood. 2012 Jun 14;119(24):5871-8. doi: 10.1182/blood-2012-01-401620. Epub 2012 May 4. Blood. 2012. PMID: 22563084 Free article.

7

Concizumab promotes haemostasis via a tissue factor-factor VIIa-dependent mechanism supporting prophylactic treatment of haemophilia: Results from a rabbit haemophilia bleeding model.

Lauritzen B, Hilden I. Lauritzen B, et al. Among authors: hilden i. Haemophilia. 2019 Nov;25(6):e379-e382. doi: 10.1111/hae.13861. Epub 2019 Oct 14. Haemophilia. 2019. PMID: 31609513 No abstract available.

8

Pharmacokinetics of an anti-TFPI monoclonal antibody (concizumab) blocking the TFPI interaction with the active site of FXa in Cynomolgus monkeys after iv and sc administration.

Agersø H, Overgaard RV, Petersen MB, Hansen L, Hermit MB, Sørensen MH, Petersen LC, Hilden I. Agersø H, et al. Among authors: hilden i. Eur J Pharm Sci. 2014 Jun 2;56:65-9. doi: 10.1016/j.ejps.2014.02.009. Epub 2014 Feb 22. Eur J Pharm Sci. 2014. PMID: 24568891

9

Thrombin generation potential in the presence of concizumab and rFVIIa, APCC, rFVIII, or rFIX: In vitro and ex vivo analyses.

Kjalke M, Kjelgaard-Hansen M, Andersen S, Hilden I. Kjalke M, et al. Among authors: hilden i. J Thromb Haemost. 2021 Jul;19(7):1687-1696. doi: 10.1111/jth.15323. Epub 2021 May 6. J Thromb Haemost. 2021. PMID: 33819375 Free PMC article.

10

Administration of recombinant FVIIa (rFVIIa) to concizumab-dosed monkeys is safe, and concizumab does not affect the potency of rFVIIa in hemophilic rabbits.

Lauritzen B, Olling J, Abel KL, Augustsson C, Balling K, Bjelke M, Hegelund AC, Hilden I. Lauritzen B, et al. Among authors: hilden i. J Thromb Haemost. 2019 Mar;17(3):460-469. doi: 10.1111/jth.14380. Epub 2019 Feb 20. J Thromb Haemost. 2019. PMID: 30614620 Free article.

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