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Page 1
A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis.
Manjunatha UH, Vinayak S, Zambriski JA, Chao AT, Sy T, Noble CG, Bonamy GMC, Kondreddi RR, Zou B, Gedeck P, Brooks CF, Herbert GT, Sateriale A, Tandel J, Noh S, Lakshminarayana SB, Lim SH, Goodman LB, Bodenreider C, Feng G, Zhang L, Blasco F, Wagner J, Leong FJ, Striepen B, Diagana TT. Manjunatha UH, et al. Among authors: leong fj. Nature. 2017 Jun 15;546(7658):376-380. doi: 10.1038/nature22337. Epub 2017 May 31. Nature. 2017. PMID: 28562588 Free PMC article.
Cryptosporidiosis Drug Discovery: Opportunities and Challenges.
Manjunatha UH, Chao AT, Leong FJ, Diagana TT. Manjunatha UH, et al. Among authors: leong fj. ACS Infect Dis. 2016 Aug 12;2(8):530-7. doi: 10.1021/acsinfecdis.6b00094. Epub 2016 Jul 22. ACS Infect Dis. 2016. PMID: 27626293 Review.
A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel Imidazolopiperazine KAF156 to assess its safety, tolerability, and pharmacokinetics in healthy adult volunteers.
Leong FJ, Zhao R, Zeng S, Magnusson B, Diagana TT, Pertel P. Leong FJ, et al. Antimicrob Agents Chemother. 2014 Nov;58(11):6437-43. doi: 10.1128/AAC.03478-14. Epub 2014 Aug 18. Antimicrob Agents Chemother. 2014. PMID: 25136017 Free PMC article. Clinical Trial.
A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel antimalarial Spiroindolone KAE609 (Cipargamin) to assess its safety, tolerability, and pharmacokinetics in healthy adult volunteers.
Leong FJ, Li R, Jain JP, Lefèvre G, Magnusson B, Diagana TT, Pertel P. Leong FJ, et al. Antimicrob Agents Chemother. 2014 Oct;58(10):6209-14. doi: 10.1128/AAC.03393-14. Epub 2014 Aug 11. Antimicrob Agents Chemother. 2014. PMID: 25114127 Free PMC article. Clinical Trial.
Spiroindolone KAE609 for falciparum and vivax malaria.
White NJ, Pukrittayakamee S, Phyo AP, Rueangweerayut R, Nosten F, Jittamala P, Jeeyapant A, Jain JP, Lefèvre G, Li R, Magnusson B, Diagana TT, Leong FJ. White NJ, et al. Among authors: leong fj. N Engl J Med. 2014 Jul 31;371(5):403-10. doi: 10.1056/NEJMoa1315860. N Engl J Med. 2014. PMID: 25075833 Free PMC article. Clinical Trial.
Antimalarial Activity of KAF156 in Falciparum and Vivax Malaria.
White NJ, Duong TT, Uthaisin C, Nosten F, Phyo AP, Hanboonkunupakarn B, Pukrittayakamee S, Jittamala P, Chuthasmit K, Cheung MS, Feng Y, Li R, Magnusson B, Sultan M, Wieser D, Xun X, Zhao R, Diagana TT, Pertel P, Leong FJ. White NJ, et al. Among authors: leong fj. N Engl J Med. 2016 Sep 22;375(12):1152-60. doi: 10.1056/NEJMoa1602250. N Engl J Med. 2016. PMID: 27653565 Free PMC article. Clinical Trial.
Bioavailability of Lumefantrine Is Significantly Enhanced with a Novel Formulation Approach, an Outcome from a Randomized, Open-Label Pharmacokinetic Study in Healthy Volunteers.
Jain JP, Leong FJ, Chen L, Kalluri S, Koradia V, Stein DS, Wolf MC, Sunkara G, Kota J. Jain JP, et al. Among authors: leong fj. Antimicrob Agents Chemother. 2017 Aug 24;61(9):e00868-17. doi: 10.1128/AAC.00868-17. Print 2017 Sep. Antimicrob Agents Chemother. 2017. PMID: 28630183 Free PMC article. Clinical Trial.
Safety, Pharmacokinetics, and Causal Prophylactic Efficacy of KAF156 in a Plasmodium falciparum Human Infection Study.
Kublin JG, Murphy SC, Maenza J, Seilie AM, Jain JP, Berger D, Spera D, Zhao R, Soon RL, Czartoski JL, Potochnic MA, Duke E, Chang M, Vaughan A, Kappe SHI, Leong FJ, Pertel P, Prince WT; KAF156 Study Team. Kublin JG, et al. Among authors: leong fj. Clin Infect Dis. 2021 Oct 5;73(7):e2407-e2414. doi: 10.1093/cid/ciaa952. Clin Infect Dis. 2021. PMID: 32644127 Free PMC article. Clinical Trial.
31 results