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A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis.
Manjunatha UH, Vinayak S, Zambriski JA, Chao AT, Sy T, Noble CG, Bonamy GMC, Kondreddi RR, Zou B, Gedeck P, Brooks CF, Herbert GT, Sateriale A, Tandel J, Noh S, Lakshminarayana SB, Lim SH, Goodman LB, Bodenreider C, Feng G, Zhang L, Blasco F, Wagner J, Leong FJ, Striepen B, Diagana TT. Manjunatha UH, et al. Among authors: chao at. Nature. 2017 Jun 15;546(7658):376-380. doi: 10.1038/nature22337. Epub 2017 May 31. Nature. 2017. PMID: 28562588 Free PMC article.
Cryptosporidiosis Drug Discovery: Opportunities and Challenges.
Manjunatha UH, Chao AT, Leong FJ, Diagana TT. Manjunatha UH, et al. Among authors: chao at. ACS Infect Dis. 2016 Aug 12;2(8):530-7. doi: 10.1021/acsinfecdis.6b00094. Epub 2016 Jul 22. ACS Infect Dis. 2016. PMID: 27626293 Review.
Lead optimization of spiropyrazolopyridones: a new and potent class of dengue virus inhibitors.
Zou B, Chan WL, Ding M, Leong SY, Nilar S, Seah PG, Liu W, Karuna R, Blasco F, Yip A, Chao A, Susila A, Dong H, Wang QY, Xu HY, Chan K, Wan KF, Gu F, Diagana TT, Wagner T, Dix I, Shi PY, Smith PW. Zou B, et al. ACS Med Chem Lett. 2015 Feb 2;6(3):344-8. doi: 10.1021/ml500521r. eCollection 2015 Mar 12. ACS Med Chem Lett. 2015. PMID: 25878766 Free PMC article.
Small molecule inhibitors that selectively block dengue virus methyltransferase.
Lim SP, Sonntag LS, Noble C, Nilar SH, Ng RH, Zou G, Monaghan P, Chung KY, Dong H, Liu B, Bodenreider C, Lee G, Ding M, Chan WL, Wang G, Jian YL, Chao AT, Lescar J, Yin Z, Vedananda TR, Keller TH, Shi PY. Lim SP, et al. Among authors: chao at. J Biol Chem. 2011 Feb 25;286(8):6233-40. doi: 10.1074/jbc.M110.179184. Epub 2010 Dec 8. J Biol Chem. 2011. PMID: 21147775 Free PMC article.
33 results