O'Connell J - Search Results

1

Synergistic interactions with PI3K inhibition that induce apoptosis.

Zwang Y, Jonas O, Chen C, Rinne ML, Doench JG, Piccioni F, Tan L, Huang HT, Wang J, Ham YJ, O'Connell J, Bhola P, Doshi M, Whitman M, Cima M, Letai A, Root DE, Langer RS, Gray N, Hahn WC. Zwang Y, et al. Elife. 2017 May 31;6:e24523. doi: 10.7554/eLife.24523. Elife. 2017. PMID: 28561737 Free PMC article.

2

SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization.

Dai C, Rennhack JP, Arnoff TE, Thaker M, Younger ST, Doench JG, Huang AY, Yang A, Aguirre AJ, Wang B, Mun E, O'Connell JT, Huang Y, Labella K, Talamas JA, Li J, Ilic N, Hwang J, Hong AL, Giacomelli AO, Gjoerup O, Root DE, Hahn WC. Dai C, et al. Cell Rep. 2021 Jul 27;36(4):109443. doi: 10.1016/j.celrep.2021.109443. Cell Rep. 2021. PMID: 34320363 Free PMC article.

3

TRAF2 is an NF-κB-activating oncogene in epithelial cancers.

Shen RR, Zhou AY, Kim E, O'Connell JT, Hagerstrand D, Beroukhim R, Hahn WC. Shen RR, et al. Oncogene. 2015 Jan 8;34(2):209-16. doi: 10.1038/onc.2013.543. Epub 2013 Dec 23. Oncogene. 2015. PMID: 24362534 Free PMC article.

4

A Wnt-bmp feedback circuit controls intertissue signaling dynamics in tooth organogenesis.

O'Connell DJ, Ho JW, Mammoto T, Turbe-Doan A, O'Connell JT, Haseley PS, Koo S, Kamiya N, Ingber DE, Park PJ, Maas RL. O'Connell DJ, et al. Sci Signal. 2012 Jan 10;5(206):ra4. doi: 10.1126/scisignal.2002414. Sci Signal. 2012. PMID: 22234613 Free PMC article.

5

Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway.

Cooke VG, LeBleu VS, Keskin D, Khan Z, O'Connell JT, Teng Y, Duncan MB, Xie L, Maeda G, Vong S, Sugimoto H, Rocha RM, Damascena A, Brentani RR, Kalluri R. Cooke VG, et al. Cancer Cell. 2012 Jan 17;21(1):66-81. doi: 10.1016/j.ccr.2011.11.024. Cancer Cell. 2012. PMID: 22264789 Free PMC article.

6

VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization.

O'Connell JT, Sugimoto H, Cooke VG, MacDonald BA, Mehta AI, LeBleu VS, Dewar R, Rocha RM, Brentani RR, Resnick MB, Neilson EG, Zeisberg M, Kalluri R. O'Connell JT, et al. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16002-7. doi: 10.1073/pnas.1109493108. Epub 2011 Sep 12. Proc Natl Acad Sci U S A. 2011. PMID: 21911392 Free PMC article.

7

Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer.

Becker LM, O'Connell JT, Vo AP, Cain MP, Tampe D, Bizarro L, Sugimoto H, McGow AK, Asara JM, Lovisa S, McAndrews KM, Zielinski R, Lorenzi PL, Zeisberg M, Raza S, LeBleu VS, Kalluri R. Becker LM, et al. Cell Rep. 2020 Jun 2;31(9):107701. doi: 10.1016/j.celrep.2020.107701. Cell Rep. 2020. PMID: 32492417 Free PMC article.

8

Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis.

LeBleu VS, Teng Y, O'Connell JT, Charytan D, Müller GA, Müller CA, Sugimoto H, Kalluri R. LeBleu VS, et al. Nat Med. 2013 Feb;19(2):227-31. doi: 10.1038/nm.2989. Epub 2013 Jan 27. Nat Med. 2013. PMID: 23353556 Free PMC article.

9

Origin and function of myofibroblasts in kidney fibrosis.

LeBleu VS, Taduri G, O'Connell J, Teng Y, Cooke VG, Woda C, Sugimoto H, Kalluri R. LeBleu VS, et al. Nat Med. 2013 Aug;19(8):1047-53. doi: 10.1038/nm.3218. Epub 2013 Jun 30. Nat Med. 2013. PMID: 23817022 Free PMC article.

10

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis.

LeBleu VS, O'Connell JT, Gonzalez Herrera KN, Wikman H, Pantel K, Haigis MC, de Carvalho FM, Damascena A, Domingos Chinen LT, Rocha RM, Asara JM, Kalluri R. LeBleu VS, et al. Nat Cell Biol. 2014 Oct;16(10):992-1003, 1-15. doi: 10.1038/ncb3039. Epub 2014 Sep 21. Nat Cell Biol. 2014. PMID: 25241037 Free PMC article.

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