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Efficient protein production inspired by how spiders make silk.
Kronqvist N, Sarr M, Lindqvist A, Nordling K, Otikovs M, Venturi L, Pioselli B, Purhonen P, Landreh M, Biverstål H, Toleikis Z, Sjöberg L, Robinson CV, Pelizzi N, Jörnvall H, Hebert H, Jaudzems K, Curstedt T, Rising A, Johansson J. Kronqvist N, et al. Among authors: jornvall h. Nat Commun. 2017 May 23;8:15504. doi: 10.1038/ncomms15504. Nat Commun. 2017. PMID: 28534479 Free PMC article.
A pH-dependent dimer lock in spider silk protein.
Landreh M, Askarieh G, Nordling K, Hedhammar M, Rising A, Casals C, Astorga-Wells J, Alvelius G, Knight SD, Johansson J, Jörnvall H, Bergman T. Landreh M, et al. Among authors: jornvall h. J Mol Biol. 2010 Nov 26;404(2):328-36. doi: 10.1016/j.jmb.2010.09.054. Epub 2010 Sep 29. J Mol Biol. 2010. PMID: 20887730
Carbonic anhydrase generates CO2 and H+ that drive spider silk formation via opposite effects on the terminal domains.
Andersson M, Chen G, Otikovs M, Landreh M, Nordling K, Kronqvist N, Westermark P, Jörnvall H, Knight S, Ridderstråle Y, Holm L, Meng Q, Jaudzems K, Chesler M, Johansson J, Rising A. Andersson M, et al. Among authors: jornvall h. PLoS Biol. 2014 Aug 5;12(8):e1001921. doi: 10.1371/journal.pbio.1001921. eCollection 2014 Aug. PLoS Biol. 2014. PMID: 25093327 Free PMC article.
High intracellular stability of the spidroin N-terminal domain in spite of abundant amyloidogenic segments revealed by in-cell hydrogen/deuterium exchange mass spectrometry.
Kaldmäe M, Leppert A, Chen G, Sarr M, Sahin C, Nordling K, Kronqvist N, Gonzalvo-Ulla M, Fritz N, Abelein A, Laίn S, Biverstål H, Jörnvall H, Lane DP, Rising A, Johansson J, Landreh M. Kaldmäe M, et al. Among authors: jornvall h. FEBS J. 2020 Jul;287(13):2823-2833. doi: 10.1111/febs.15169. Epub 2019 Dec 20. FEBS J. 2020. PMID: 31815338 Free PMC article.
Proinsulin C-peptide interferes with insulin fibril formation.
Landreh M, Stukenborg JB, Willander H, Söder O, Johansson J, Jörnvall H. Landreh M, et al. Among authors: jornvall h. Biochem Biophys Res Commun. 2012 Feb 17;418(3):489-93. doi: 10.1016/j.bbrc.2012.01.051. Epub 2012 Jan 18. Biochem Biophys Res Commun. 2012. PMID: 22281499
739 results